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http://dx.doi.org/10.7742/jksr.2015.9.7.509

Characteristic Changes Observation of N-isopropylacrylamide Phantom by Repeated Ultrasound Irradiation  

Kim, Ju-Young (Department of Biomedical Engineering, Inje University)
Kim, Jae-Young (Department of Biomedical Engineering, Inje University)
Noh, Si-Cheol (Department of Radiological Science, International University of Korea)
Choi, Heung-Ho (Department of Biomedical Engineering, Inje University)
Publication Information
Journal of the Korean Society of Radiology / v.9, no.7, 2015 , pp. 509-513 More about this Journal
Abstract
In this study, we evaluated the thermal denaturation characteristics of reusable NIPAM tissue mimicking (TM) Phantom by measuring the thermal sensitivity. And the changes of acoustic characteristic and thermal denaturation shape in NIPAM TM phantom according to the number of re-use time and re-use period were observed. With the result, as the sonication time is increased, the sound velocity of NIPAM phantom was decreased by 100 m/s and the attenuation was increased slightly. However, the changes according to the re-use period was not observed. In the thermal denaturation shape and size observation by ultrasound sonicaton, the remarkable changes have not been confirmed. With the result of this study, NIPAM Phantom was considered appropriate to evaluate and predict the effect of therapeutic ultrasound by in repeated sonication test.
Keywords
N-isopropylacrylamide; therapeutic ultrasound; repeated ultrasound sonication; tissue mimic phantom; thermal sensitivity;
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Times Cited By KSCI : 1  (Citation Analysis)
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1 X. G. Liang, X. S. Ge, Y. P. Zhang, et al., "A convenient method of measuring the thermal conductivity of biological tissue." Phys. Med. Biol., Vol. 36, No. 12, pp.1599-1605, 1991.   DOI
2 G. ter Haar, "Therapeutic applications of ultrasound", Progress in biophysics and molecular biology, Vol. 93, No. 1, pp.111-129, 2007.   DOI
3 K. Tauer, D. Gau, S. Schulze, et al., "Thermal property changes of poly (N-isopropylacrylamide) microgel particles and block copolymers", Colloid Polym Sci, Vol. 287, No. 3, pp.299-312.2009.   DOI
4 M. K. Sun, J. Shieh, C. W. Lo, et al., "Reusable tissue-mimicking hydrogel phantoms for focused ultrasound ablation", Ultrasonics sonochemistry, Vol. 23, pp.399-405, 2015.   DOI
5 L. M. Cannon, A. J. Fagan, J. E. Browne, "Novel Tissue Mimicking Materials High Frequency Breast Ultrasound Phantoms", Ultrasound in Med. & Biol., Vol.37, No. 1, pp.122-135, 2011.   DOI
6 M. McDonald, S. Lochhead, R. Chopra et al., "Multi-modality tissue-mimicking phantom for thermal therapy," Physics in Medicine and Biology, Vol. 49, No. 13, pp.2767-2778, 2004.   DOI
7 X. Cheng, H. E. Canavan, M. J. Stein, et al., "Surface chemical and mechanical properties of plasma-polymerized N-isopropylacrylamide", Langmuir, Vol. 21, No. 17, pp.7833-7841, 2005.   DOI
8 A. F. Prokop, S. Vaezy, M. L. Noble, et al., "Polyacrylamide gel as an acoustic coupling medium for focused ultrasound therapy", Ultrasound in medicine & biology, Vol. 29, No. 9, pp.1351-1358, 2003.   DOI
9 R. Ortega, A. Tellez, L. Leija et al., "Measurement of Ultrasonic properties of Muscle and Blood Biological Phantom", Physics Procedia., Vol. 3, No.1, pp.627-634, 2009.   DOI
10 J. H. Min, J. Y. Kim, S. C. Noh, et al., "Development of Human-Head-Mimicking Phantom for Brain Treatment Using Focused Ultrasound", J. Korean. Soc. Radiol., Vol. 7, No. 6, pp.433-439, 2013.   DOI