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http://dx.doi.org/10.7742/jksr.2014.8.6.325

A Synthesis of Iron Oxide Based and Gadolinium Oxide Based Radiosensitizer for the Therapeutic Enhancement of Proton Beam Cancer  

Kang, Bo Sun (Department of Radiological Science, Konyang University)
Publication Information
Journal of the Korean Society of Radiology / v.8, no.6, 2014 , pp. 325-332 More about this Journal
Abstract
Metallic nanoparticles have attractive properties in biomedical applications such as diagnostics and therapeutics. Cross linked dextran coated iron oxide nanoparticles (SPIONs) and silica coated gadolinium oxide nanoparticles (SPGONs) have been synthesized as a radiosensitizer in the proton beam cancer therapy. The dextran and silicaused for the protective moieties on the SPIONs and SPGONs respectively. Size distributions of synthesized nanoparticles were confirmed 3~5 nm for SPIONs and 30~100 nm for SPGONs by transmission electron microscope (TEM). Cell survival fraction measurement and Western blot assay were performed to evaluate the radiosensitization effects of synthesized radiosensitizer. The calculated radiosensitization of SPIONs and SPGONs at 90 % cell death from the measured cell survival curves were 1.23 and 1.03 respectively. Western blotting results also show the same consistent results that the amount of released cytochrome c from mitochondria was considerably increased for the cancer cells taken up SPIONs.
Keywords
Metallic nanoparticle; Radiosensitizer; Iron oxide nanoparticle; Gadolinium oxide nanoparticle; Cytochrom C; Western blotting;
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