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http://dx.doi.org/10.7742/jksr.2011.5.3.143

Evaluation of Usefulness of SPIO (Superparamagnetic iron oxide) Contrast Agent in MRCP (Magnetic resonance cholangiopancreatography)  

Hong, In-Sik (Department of Computer Science and Soonchunhyang University)
Lee, Hae-Kak (Department of Computer Science and Soonchunhyang University)
Cho, Jae-Hwan (Department of Radiological Science, Gyeonesan University College)
Kim, Hyeon-Ju (Department of Radiology, Soonchunhyang University. Hospital)
Jang, Hyun-Cheol (Department of Radiology, Soonchunhyang University. Hospital)
Park, Cheol-Soo (Department of Radiological Science, Hanlym College)
Lee, Sun-Yeob (Department of Radiological Science, Hanlym College)
Goo, Eun-Hoe (Department of Radiology, Seoul Nationnal University Hospital)
Dong, Kyung-Rae (Department of Radiological Technology, Gwangju Health College University, Department of Radiological Technology)
Cho, Moo-Seong (Department of Radiological Science, Gyeonesan University College)
Publication Information
Journal of the Korean Society of Radiology / v.5, no.3, 2011 , pp. 143-148 More about this Journal
Abstract
The purpose of this study was to examine the usefulness of SPIO contrast agent in Magnetic Resonance Cholangiopancreatography (MRCP) by performing a quantitative comparative analysis in patients undergoing MRCP for gallbladder stones with and without oral injection of SPIO (Superparamagnetic iron oxide) contrast agent. The subjects were 36 patients undergoing MRCP for suspected gallbladder stones between January 2009 and February 2010 and they were divided into halves to compare the two groups of with and without SPIO agent. For each subject in both the injected and non-injected group, T2-weighted images on a 1.5T MR scanner were obtained, using both the breath-holding and respiratory-triggered methods, respectively. The following regions were measured; for breath-hold T2-weighted images, the measurement regions were located at the central part of the gallbladder, and the areas 15 mm away from its center, toward the front and back, respectively, which were chosen to include surrounding tissues, while for respiratory-triggered T2-weighted images, at the central part of the gallbladder, and segment 5 and 6 of liver. In a quantitative analysis, average signal to noise ratio (SNR) in each of regions of interest (ROI) for each group were calculated and then average contrast to noise ratio (CNR) in each of ROI were obtained by using the SNR in the gallbladder as the basis to compare and analyze the values between the two groups. The CNR were higher for the injected group in those regions.
Keywords
SPIO (Superparamagnetic iron oxide); gallbladder stones; Signal to noise ratio (SNR); Contrast to noise ratio (CNR);
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