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http://dx.doi.org/10.17946/JRST.2020.43.2.97

Comparison of the Measurement of the Injection Rate of Radioactive Drugs Using 99mTc in Nuclear Medicine  

Son, Sang-Joon (Department of Nuclear Medicine, Daegu Patima Hospital)
Park, Jeong-Kyu (Department of Radiological Technology, Daegu Health College)
Jung, Dong-Kyung (Department of Radiological Technology, Daegu Health College)
Park, Myeong-Hwan (Department of Radiological Technology, Daegu Health College)
Publication Information
Journal of radiological science and technology / v.43, no.2, 2020 , pp. 97-103 More about this Journal
Abstract
This study was conducted by SPECT test at the Department of Nuclear Medicine at Daegu P Hospital from June 1 to October 31, 2019. A 3-way injection material was mounted among inpatients, and a syringe that was administered with radiopharmaceuticals using a 99mTc labeled compound was secured. We tried to find a way to calculate the dose rate of each radiopharmaceutical and increase the dose rate. As a result of measuring the radioactivity of radio-pharmaceuticals using 99mTc, the average dose rate of 60 syringes of all 6 radiopharmaceuticals was 93.26±7.34%, and the average dose rate of 99mTc-DMSA was 77.72%, 15.54% lower than the total. As a way to increase the dosing rate, the average dose rate diluted twice with the remaining amount of syringe after administration using normal saline increased to 95.37±6.99%, and the average dose rate diluted three times increased to 96.32±6.86%. The corresponding sample t-test to compare the pre- and post-dose rates at 1 dilution and 2 and 3 dilutions. As a result of the dilution and 2 dilutions, the probability of significance was 0.013, which was significantly higher than the dilution(p<0.05). The probability of significance for dilution 1 and dilution 3 was 0.016, which was significantly higher than in one dilution(p<0.05). The sum of the average dose rate using the experimental 3-way line was the highest with 98.85±1.42% of 99mTc, 99mTc-ECD 98.82±1.26%, 99mTc-Mebrofenin 98.82 ± 1.16%, 99mTc-HDP 98.74 ± 1.91%, 99mTc -MIBI was 98.69 ± 1.48%, and 99mTc-DMSA was the lowest with 86.47 ± 4.74%. When the number of dilutions was 5 times using 0.5 cc of normal saline and when the number of dilutions was 5 times using 1 cc of normal saline, when the number of dilutions was 5 times using 0.5 cc of normal saline and 1 cc of nomal saline When the number of dilutions was 5 times and the syringe volume was 0.5 cc, there was a statistically significant difference (p<0.05). There was a statistically significant difference when the number of dilutions was 5 times using 1 cc of nomal saline and the number of dilutions was 5 times using 1 cc of normal saline, and the syringe volume was 0.5 cc (p<0.05).
Keywords
$^{99m}Tc$-radiopharmaceuticals; Normal saline; Administration rate; Dilution count;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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1 Chung JK, Lee MC. Nuclear Medicine. Seoul: Korea Medical Book publisher; 2008.
2 Kim GJ, Bae SH, Kim KJ, Oh HK. Effect of Gamma Energy of Positron Emission Radionuclide on X-Ray CT Image. Journal of the Korea Academia-Industrial cooperation Society. 2011;12(10):4418-24.   DOI
3 Seon CR, Gil JW. Study on Development of Patient Effective Dose Calculation Program of Nuclear Medicine Examination. Journal of the Korea Academia-Industrial cooperation Society. 2017;18(3):657-65.   DOI
4 Choi SY, Go Sj, Kang SS, Kim CS, Kim JH. Automated Functional Morphology Measurement Using Cardiac SPECT Images. Journal of Radiological Science and Technology. 2012:35(2):133-9.
5 Choi DC, Kim YS, Cho KM, Kim HJ, Seo HG. Consideration of a bacteria contamination management in the dispensation of 99mTc radiopharmaceutical. Nuclear Medicine and Technology Society. 2018;22(2):84-7.
6 James RB, Clemens D, Brit F, Brendan M, Geraldine OR, Helen R, et al. The Radiopharmacy A technologist's Guide. Vienna: European Association of Nuclear Medicine; 2008.
7 https://blog.naver.com/qcci?Redirect=Log&logNo=140006256548
8 Treves ST. Pediatric Nuclear Medicine. 2nd ed. New York: Springer-Verlag; 1995.
9 Kim JH, Choi SY, Go Sj, Kang SS, Kim CS. Automated Functional Morphology Measurement Using Cardiac SPECT Images. Journal of Radiological Science and Technology. 2012;35(2):133-9.
10 Pandey AK, Sharma SK, Sharma P, Gupta P, Kumar P. Development of a radiopharmaceutical dose calculator for pediatric patients undergoing diagnostic nuclear medicine studies. Indian J Nucl Med. 2013;28(2):75-8.   DOI
11 Pandey AK, Sharma SK, Sharma P, Gupta P, Kumar P, Development of a radiopharmaceutical dose calculator for pediatric patients undergoing diagnostic nuclear medicine studies. Indian J Nucl Med. 2013;28(2):75-78.   DOI
12 Treves ST. Pediatric Nuclear Medicine. 2nd ed. New York: Springer-Verlag; 1995.
13 Galbraith W, Chen X, Talley K, Grantham V. Assessment of $^{99m}Tc$-succimer residual activity using inert nonreactive syringes. Journal of Nuclear Medicine Technology. 2015;43(1):61-3.   DOI
14 Bauwens M. Retention of $^{99m}Tc$-DMSA(III) and $^{99m}Tc$-nanocolloid in different syringes affects imaging quality. Nuclear Medicine Communications. 2014;35(4):433-7.   DOI
15 Go CS. Nuclear medicine. 4rd ed. Seoul: Korea medicine; 2013.
16 Gil JW. Comparing of the Administered Activities and the Effective Dose of the Various Pediatric Dose Formulas of Nuclear Medicine. Journal of the Korean Society for Convergence. 2017;8(8):147-54.