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http://dx.doi.org/10.17946/JRST.2017.40.2.13

Effect of Glucose Level on Brain FDG-PET Images  

Kim, In-Yeong (Department of Radiological Science, Gachon University)
Lee, Yong-ki (Department of Radiological Science, Gachon University)
Ahn, Sung-Min (Department of Radiological Science, Gachon University)
Publication Information
Journal of radiological science and technology / v.40, no.2, 2017 , pp. 275-280 More about this Journal
Abstract
In addition to tumors, normal tissues, such as the brain and myocardium can intake $^{18}F$-FDG, and the amount of $^{18}F$-FDG intake by normal tissues can be altered by the surrounding environment. Therefore, a process is necessary during which the contrasts of the tumor and normal tissues can be enhanced. Thus, this study examines the effects of glucose levels on FDG PET images of brain tissues, which features high glucose activity at all times, in small animals. Micro PET scan was performed on fourteen mice after injecting $^{18}F$-FDG. The images were compared in relation to fasting. The findings showed that the mean SUV value w as 0.84 higher in fasted mice than in non-fasted mice. During observation, the images from non-fasted mice showed high accumulation in organs other than the brain with increased surrounding noise. In addition, compared to the non-fasted mice, the fasted mice showed higher early intake and curve increase. The findings of this study suggest that fasting is important in assessing brain functions in brain PET using $^{18}F$-FDG. Additional studies to investigate whether caffeine levels and other preprocessing items have an impact on the acquired images would contribute to reducing radiation exposure in patients.
Keywords
Glucose; Standard uptake value(SUV); PET; FDG;
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