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http://dx.doi.org/10.17946/JRST.2016.39.3.20

The Effect of Squalene on Inflammation Factors Induced by Candida Albicans in Vivo Studies  

Lee, Jun-Haeng (Department of Radiology, Nambu University)
Publication Information
Journal of radiological science and technology / v.39, no.3, 2016 , pp. 443-449 More about this Journal
Abstract
In the present study, whether squalene treatment relives inflammatory reactions induced by Candida albicans was checked. The experiment was conducted in vivo using seven experimental animals (ICR mice) per experimental group. Among C. albicans-induced inflammatory factors, TNF-${\alpha}$, IL-6, and NO were observed using the ELISA kits method. Through the experiment, the following conclusions were obtained. 1. In the group infected with C. albicans, it could be identified that squalene treatment was inducing NO generation in renal tissues both on the 1st and 3rd days (p < 0.05). 2. In the group pre-treated(intraperitoneal administration) with SQ (80ml/kg) once per day for seven days and infected with C. albicans, it could be identified that squalene treatment was inducing TNF-${\alpha}$ generation in renal tissues only on the 3rd day(p < 0.05). 3. In the group pre-treated(intraperitoneal administration) with SQ (80ml/kg) once per day for seven days and infected with C. albicans, it could be identified that squalene treatment was inducing IL-6 generation in renal tissues only on the 3rd day(p < 0.05). In conclusion, it could be seen that for squalene to suppress C. albicans-induced inflammatory factors, preemptively supplying SQ should be effective. Therefore, effects for recovery from C. albicans-induced immunodepression can be expected from SQ treatment.
Keywords
Candida albicans; Inflammatory reactions; Squalene; Renal tissues; In vivo;
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1 Netea, M.G, Gijzen, K, Coolen, N, "et al", "Human dendritic cells are less potent at killing Candida albicans than both monocytes and macrophages." Microbes and Infect. 6:985-989, 2004   DOI
2 Debjani, S, Piu, S, Sunita, G, Surajit, B and Mitali, C. "Anti-inflammation effect of allypyrocatechol in LPS-induded macropharges is mediated by suppression of iNOS and COX-2 via the NF-${\kappa}$B pathway." Int. Immunopharmacol. 8:1264-1271, 2008   DOI
3 Park, J.H, Lee, K.W, Chon, S.E, Kim, S.J, Lee, B.B and Joh, J.W. "Candida polyarthritis in a renal transplant patients." Kor. J. Soc. Transplant. 15:237-239, 2001
4 Dennis, J.S and Michael, A.M. "Mammalian nitrate biosynthesis: Mouse macrophages produed nitrate and nitrate in response E.coli lipopolysaccharide." Proc. Natl. Acad . Sci. 82(7738-7742), 1985   DOI
5 Kim, K.H, Lee, G, Lee, H.S, Kim, C.D, Hyun, J.H and Ahn, B.O. "The serum tumor necrosis factor-${\alpha}$ and interleukin-1${\beta}$ in experimental acute pancreatitis of the rats." Kor. J. Gastroentero. 34:238-244, 1999
6 Hirano, T. "Molecul-Biology of cytokines." World science. 1-3, 2002
7 Chinthalapally, V.R, Harold, L.N and Bandaru, S.R. "Chemopreventive effect of squalene on colon cancer." Carcinogenesis. 19(2):287-290, 1998   DOI
8 Strandberg, T.E, Tilvis, R.S and Miettinen, T.A. "Effects of cholestyramin.e and squalene feeding on hepatic and serum plant sterols in the rat." Lipid. 24(8):705-708, 1989   DOI
9 Saint-Leger, D, Bague, A, Cohen, E and Chivot, M. "A possible role for squalene in the pathogenesis of acne. In vitro study of squalene oxidation." Br. J. Dermatol. 114:535-542, 1986   DOI
10 Smith, T.J. "Squalene: potential chemopreventive agent." Expert. Opin. Investig. Drugs. 9(8): 1841-1848, 2000   DOI
11 Harold, L.N. "Squalene, olive oil, and cancer risk: A review and hypothesis Cancer." Epidermilogy. Biomarkers. Prevent. 6:1101-1103, 1997
12 Kim, M.S, Sung, M.J, Seo, S.B, Yoo, S.J, Lim, W.K and Kim, H.M. "Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid ${\beta}$peptide and interleukin-1${\beta}$." Neurosci. Letter. 321:105-109, 2002   DOI
13 Byun, B.H. "Effects of Inonotus obliquus Ethanol Extact on Cytokine Expression in Raw 264.7 cells" Kor. J. Herbology: 20(2):55-60, 2005
14 Yee, S.T, Jeong, Y.R, Ha, M.H and Kim, S.H. "Induction of nitric oxide and TNF-${\alpha}$ by herbal plant extracts in mouse macrophages." J. Kor. Soc. Food. Sci. Nutr. 29(2):342-348, 2000
15 Oh, S.W, Hong, S.P, Kim, H.J and Choi, Y.J. "Antimicrobial effects of chitosan on E. coli O157:H7, Staphyloccus and Candida albicans." Kor. J. Food. Sci. Technol. 32(1):218-224, 2000
16 Yoo, S.C, Suh, J.S. "Antifungal actions of crude drug water extracts on Candida albicans(I)." Kor. J. Pharmacog. 5(3):147-154, 1974