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http://dx.doi.org/10.17946/JRST.2016.39.1.03

The Protective Effects of Black Garlic Extract for Blood and Intestinal Mucosa to Irradiation  

Jung, Do-Young (Dongnam Institute of Radiological & Medical Sciences Cancer Center)
Choi, Junhyeok (Inje University)
Kim, Joongsun (Dongnam Institute of Radiological & Medical Sciences Cancer Center)
Choi, Hyeongseok (Dongnam Institute of Radiological & Medical Sciences Cancer Center)
Bae, Minji (Dongnam Institute of Radiological & Medical Sciences Cancer Center)
Park, Wonsuk (Inje University)
Min, Byungin (Inje University)
Publication Information
Journal of radiological science and technology / v.39, no.1, 2016 , pp. 19-26 More about this Journal
Abstract
The radiation has been utilized in a number of fields, even though the use of plenty cause a variety of side effects. This study was confirmed for radiation protective effects of aged garlic to contribute to the prevention of disasters that are radiation exposure. We studied the Complete Blood cell Count(CBC) and the small intestine after feeding aged garlic extract into Sprague Dawley Rat which irradiated X-ray beam 7 and 13 Gy. Garlic extract was administered to the results in the experimental group showed a notable difference in the CBC of platelets (p<0.05), red blood cells (p<0.05) and early damaged white blood cells (p<0.05). In addition, it was confirmed that experimental group's small intestine crypt is more survival than irradiation group significantly. And experimental group has small intestine villi length almost similar to the normal group. result of the aged garlic study will be able to be of great benefit for the radiation relevant emergency management.
Keywords
Black garlic extract; Blood and intestinal mucosa; Irradiation;
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Times Cited By KSCI : 9  (Citation Analysis)
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1 Hyungkeon Roh : Radiological Accident and Acute Radiation Syndrome, Journal of Korean Societyof Clinical Toxicology, 26(3), 39-48, 2011
2 Bangju Park : Analysis of Public Perception on Radiation: with One Year after Fukushima Nuclear Accident, Journal of Radiation Protection, 37(1), 1-9, 2012   DOI
3 IAEA Safety series no. 47 : Manual on early medical treatment of possible radiation injury, Lindskoug BA, 1978
4 David P. Hickman : Management of persons contaminated with radionuclides, Journal of Radiation Protection Dosimetry, 141(2), 215-216, 2010   DOI
5 Jungsub Sin, Jeonghill Park, Sungho Kim, Hunjeong Kim, Youngchul Kim : Effects of Sun Ginseng on the Crypt Cell Survival in Mice Irradiated with High-energy X-ray, Journal of Environmental Toxicology, 22(1), 73-82, 2007
6 Montano A, Casado FJ, De Castro A, Sanchez AH, Rejano L : Vitamin Content and Amino Acid Composition of Pickled Garlic Processed with and without Fermentation, Journal of Agricultural and Food Chemistry, 52, 7324-7430, 2004   DOI
7 Eunkyung Jang, Jihyun Seo, Sampin Lee : Physiological Activity and Antioxidative Effects of Aged Black Garlic Extract, Journal of Food Science and Technology, 40(4), 443-448, 2008
8 Dongyeok Shin, Mookyoung Yoon, Youngwhan Choi et al. : Effects of Aged Black Garlic Extracts on the Tight Junction Permeability and Cell Invasion in Human Gastric Cancer Cells, Journal of Life Science, 20(4), 528-534, 2010   DOI
9 Youhee Choi, Hyungmin Jeong, Kyuhang Kyung, Beungho Ryu, Kwangyoul Lee : Aged Garlic Extract and Its Components Inhibit Platelet Aggregation in Rat, Journal of Life Science, 21(10), 1355-1363, 2011   DOI
10 Jiyoung Cha, Soojung Lee, Junghye Shin, Nakju Sung : Antioxidant and Inhibition of Nitrosodimethyl amine Formation in Marketing Black Garlics, Journal of Agriculture & Life Science, 46(2), 151-162, 2009
11 Yeongho Beak, Sangho Lee, Minho Han, Yunghyun Choi, Seunghyun Kim, Yisub Kwak : Effects of Black Garlic Supplementation and Exercise on TBARS, HSP 70 and COX-2 Expression after High-intensity Exercise, Journal of Life Science, 22(6), 772-777, 2012   DOI
12 Dillson SA. Lowe GM. Billington D. Rahman K : Dietary Supplementation with Aged Garlic Extract Reduces Plasma and Urine Concentrations of 8-iso-protaglandin F(2 Alpha) in Smoking and Nonsmoking Men and Women, Journal of Nutrition, 132, 163-170, 2002
13 Sangeun Bae, Seungyong Cho, Yongduk Won, Seonha Lee, Hyunjin Park : A Comparative Study of the Different Analytical Methods for Analysis of S-allyl Cysteine in Black Garlic by HPLC, Food Science and Technology, 46, 532-535, 2012
14 Junchul park : The Radioprotective Effects of Grifola umbellata Hot Water Extract on Mice, Korean Society of Radiological Science, v.28, no.4, 333-340, 2005
15 Nagatoshi I. Benjamin HS. Kenjiro R. Hiromichi M. Yoichi I : Antioxiant Effects of Fructosyl, Arginie, a Marillard Reaction Product in Aged Garlic Extract, Journal of Nutritional Biochemistry, 10, 373-376, 1999
16 Soojin Lee, Hyang Nam, Moonmoo Kim et al. : In vitro Inhibitory Effect of Aged Black Garlic Extract with Antioxidant Activity on MMP-2 and MMP-9 Related to Metastasis, Journal of Life Science, 20(5), 760-767, 2010   DOI
17 Haejune Lee, Joongsun Kim, Changjong Moon, Jongchoon Kim, Sungkee Jo, Sungho Kim : Relative Biological Effectiveness of Fast Neutrons in a Multiorgan Assay for Apoptosis in Mouse, Journal of Environmental Toxicology, 23, 233-239, 2008   DOI
18 Taejeong Ji : A Study on Radio-Protection Mechanism of Platelet Cells After Injection of Alliin, Korean Society of Radiological Science, v.33, no.3, 185-192, 2010