Browse > Article

The Evaluation of Composite Dose using Deformable Image Registration in Adaptive Radiotherapy for Head and Neck Cancer  

Hwang, Chul-Hwan (Dept. of Radiation Oncology, Pusan National University Hospital)
Ko, Seong-Jin (Dept. of Radiological Science, College of Health Sciences, Catholic University of Pusan)
Kim, Chang-Soo (Dept. of Radiological Science, College of Health Sciences, Catholic University of Pusan)
Kim, Jung-Hoon (Dept. of Radiological Science, College of Health Sciences, Catholic University of Pusan)
Kim, Dong-Hyun (Dept. of Radiological Science, College of Health Sciences, Catholic University of Pusan)
Choi, Seok-Yoon (Dept. of Radiological Science, College of Health Sciences, Catholic University of Pusan)
Ye, Soo-Young (Dept. of Radiological Science, College of Health Sciences, Catholic University of Pusan)
Kang, Se-Sik (Dept. of Radiological Science, College of Health Sciences, Catholic University of Pusan)
Publication Information
Journal of radiological science and technology / v.36, no.3, 2013 , pp. 227-235 More about this Journal
Abstract
In adaptive radiotherapy(ART), generated composite dose of surrounding normal tissue on overall treatment course which is using deformable image registration from multistage images. Also, compared with doses summed by each treatment plan and clinical significance is considered. From the first of May, 2011 to the last of July, 2012. Patients who were given treatment and had the head and neck cancer with 3-dimension conformal radiotherapy or intensity modulated radiotherapy, those who were carried out adaptive radiotherapy cause of tumor shrinkage and weight loss. Generated composite dose of surrounding normal tissue using deformable image registration was been possible, statistically significant difference was showed to mandible($48.95{\pm}3.89$ vs $49.10{\pm}3.55$ Gy), oral cavity($36.93{\pm}4.03$ vs $38.97{\pm}5.08$ Gy), parotid gland($35.71{\pm}6.22$ vs $36.12{\pm}6.70$ Gy) and temporomandibular joint($18.41{\pm}9.60$ vs $20.13{\pm}10.42$ Gy) compared with doses summed by each treatment plan. The results of this study show significant difference between composite dose by deformable image registration and doses summed by each treatment plan, composite dose by deformable image registration may generate more exact evaluation to surrounding normal tissue in adaptive radiotherapy.
Keywords
Adaptive Radiotherapy (ART); Deformable Image Registration; Dose Volume Histogram (DVH);
Citations & Related Records
연도 인용수 순위
  • Reference
1 Chao KS, Wippold FJ, Ozyigit G, et al.: Determination and delineation of nodal target volume for head-and-neck cancer based on patterns of failure in patients receiving definitive and postoperative IMRT, Int. J. Radiat. Oncol. Biol. Phys., 53, 1174-1184, 2002   DOI
2 Purdy JA: Current ICRI definitions and volumes: Limitations and future directions, Semin. Radiat. Oncol., 1, 27-40, 2004
3 Ahn PH, Chen CC, Ahn AI, et al.: Adaptive planning intensity-modulated radiation therapy for head and neck cancers: single-institution experience and clinical implicaitons, Int. J. Radiat. Oncol. Biol. Phys., 3, 677-685, 2011
4 Hansen EK, Bucci MK, Quivey JM, et al: Repeat CT imaging and replanning during the course of IMRT of head-and-neck cancer, Int. J. Radiat. Oncol. Biol. Phys., 64, 355-362, 2006   DOI
5 Bak JN, Jeong KK, Keum KC, et al: On-line image guided radiation therapy using cone-beam CT(CBCT), J. Korean Soc. Ther. Radiol. Oncol., 24, 294-299, 2006
6 Oh SJ, Kim SY, Suh TS, et al: How image quality affects determination of target displacement when using kV cone-beam computed tomograpy(CBCT), Korean J. Medical phys., 17, 207-211, 2006
7 Wu Q, Chi Y, Chen PY, et al: Adaptive replanning strategies accounting for shrickage in head and neck IMRT, Int. J. Radiat. Oncol. Bilo. Phys., 75, 924-932, 2009   DOI
8 Keall P: 4-dimensional computed tomography imaging and treatment planning, Semin. Radiat. Oncol., 14, 18-90, 2004
9 Zhang G, Huang TH, Feygelman V, et al: Generation of composite dose and biological effective dose(BED) ver multiple treatment modalities and multistage planning using deformable image registration, Med. Dosim., 35, 143-150, 2010   DOI
10 Lyman JT: Complicaiton probability as assessed form dose-volume histogram, Radiat. Res., 10, S13-S19, 1985
11 Oetzel D, Schraube P, Hensley F, et al: Estimation of pneumonitis risk in three- dimensional treatment planning using dose-volume histogram analysis, Int. J. Radiat. Oncol. Biol. Phys., 33, 455-460, 1995   DOI
12 ICRU Report 62(supplement to ICRU 50): Prescribing, recording and Reporting Photon Beam Therapy, International Commission on Radiation Units and Measurements, Maryland, USA, 1999
13 NEMA: Digital Imaging and Communications in Medicine(DICOM). Rosslyn, VA:National Electrical Manufacturers Association; 2001
14 Barker JL, Gargen AS, Ang KK, et al: Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT/linear accelerator system, Int. J. Radiat. Oncol. Biol. Phys., 59, 960-970, 2004   DOI
15 Lu W, Chen ML, Olivera GH, et al: Fast free-form deformable registration via calculus of variation, Phys. Med. Biol., 49, 3067-3087, 2004   DOI
16 Bhide SA, Davies M, Burke K, et al: Weekly volume and dosimetric changes during chemoradiotherapy with intensity-moudulated radiation therapy for head and neck cancer: a prospective observational study, Int. J. Radiat. Oncol. Biol. Phys., 76, 1360-1368, 2010   DOI
17 Lee C, Langen KM, Lu W, et al: Assessment of parotid gland dose changes during head and neck cancer radiotherapy using daily megavoltage computed tomography and deformabel image registration, Int. J. Radiat. Oncol. Biol. Phys., 71, 1563-1571, 2008   DOI
18 Schwartz DL, Garden AS, Thomas J, et al: Adaptive radiotherapy for head-and-neck cancer: Initial clinical outcomes from a prospective trial, Int. J. Radiat. Oncol. Biol. Phys., 83, 986-993, 2011
19 Lu W, Olivera GH, Chen Q, et al: Deformable registration of the planning image(KVCT) and the daily images(MVCT) for adaptive radiation therapy., Phys. Med. biol., 51, 4357-4374, 2006   DOI
20 ICRP Pulicaiton 86: Prevention of accidental exposures to patients undergoing radiation therapy. International Commision on Radiatiological Protection, Oxford, Pergamon Press, 2000