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Radiation-Induced IL(interleukin)-6 in Mice with Algin-Oligosaccharide Treatment  

Choi, Seong-Kwan (Dept. of Radiological Technology, Gwangju Health University)
Ji, Youn-Sang (Dept. of Radiological Technology, Gwangju Health University)
Publication Information
Journal of radiological science and technology / v.33, no.4, 2010 , pp. 321-326 More about this Journal
Abstract
To examine the radioprotective effect of algin-oligosaccharide(AOS), radiation-induced IL(interleukin)-6 in mice treated with 3 Gy whole body irradiation once were examined. In the measurement of irradiation-induced IL-6, in comparison with the irradiation control group, in both small intestine and liver tissues of the group treated with algin-oligosaccharide for 7 days prior to irradiation, was suppressed IL-6 synthesis(p < 0.001). It is considered that the protection against radiation hazard by antioxydative reaction of algin-oligosaccharide results in down control of IL-6 value in experimental groups treated with algin-oligosaccharide. In conclusion, through our study, the fact that algin-oligosaccharide has irradiation protection effects was elucidated, and simultaneously, the possibility of the use of a natural product without chemical toxicity as an irradiation protection agent was confirmed.
Keywords
Radiation-induced IL-6; Radiation-induced CYTOKINE; algin-oligosaccharide;
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