Browse > Article

The Relationship Between Serum Prostate Specific Antigen and Prostate Volume of Measured by Transrectal Ultrasonography  

Kim, Mi-Young (Dept. of Diagnostic Radiology, Dankook Univ. Hospital)
Publication Information
Journal of radiological science and technology / v.33, no.3, 2010 , pp. 239-243 More about this Journal
Abstract
Even though clinical use DRE, PSA and TRUS for screening while diagnosing prostate cancer early, however, we cannot achieve to diagnose it accurately by one method. Thus, mutual supplements are strongly required in diagnosis. It means that we should identify relationship between prostate volume and serum PSA under different ages for better diagnosis. The subjects(405 men) visited the department of diagnostic radiology in a general university hospital from January 2008 to December 2008, who was going to take the prostatic evaluation by TRUS. 13 men, who did definite diagnosis of prostate cancer before through biopsy, were excluded in this study. All data were expressed as mean and standard deviations by using SPSS 14.0 package programs and were analyzed by using one-way ANOVA to evaluate the effect of different ages. And Scheffe Post hoc comparison is accomplished in order to make significant difference in prostate volume, PSA and PSAD according to ages. Pearson correlation was used for ages, prostate volume, PSA and PSAD. According to examination, the subjects' prostate volume and serum PSA level increase as person's age. We can see significant difference between group over 70 years and group from 40 and 50 years. Moreover, age, prostate volume and serum PSA have significant positive correlation. Even though we can get variations in serum PSA level by changing prostate volume according to ages, it is worthwhile to mention that more strong association for prostate volume is observed than ages in elevation of serum PSA. Therefore, it is strongly recommended to consider prostate volume weightly when it comes to evaluate for men with elevated PSA level. Finally, TRUS is an excellent extra equipment to diagnose prostate cancer because it can contribute to early diagnose and pertinent treatment of prostate cancer.
Keywords
prostate cancer; PSA; TRUS;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Oesterling, J. E., Jacohson, S. J., Chute, C. G., Guess, H. A., Girman, C. J., Panser, L. A. et al.: Serum Prostate-Specific Antigen in a Community-Based Population of Healthy Men Establishment of Age-Specific Reference Ranges, JAMA, 270, 860-864, 1993   DOI   ScienceOn
2 Collins, G. N., Lee, R. J., Mckelvie, G. B., Rogers, A. C., Hehir, M.: Relationship Between Prostate Specific Antigen, Prostate Volume and Age in the Benign Prostate, Br J Urol., 71, 445-450, 1993   DOI   ScienceOn
3 Meshref, A. W., Bazinet, M., Trudel, C., Aronson, S., Peloquin, F., Nachabe, M. et al.: Role of Prostate-Specific Antigen Denstiy After Applying Age-Specific Prostate Specific Antigen Reference Ranges, J Urol., 45, 972-979, 1995   DOI   ScienceOn
4 Babain, R. J., Miyashita, H., Evana, R. B.: The Distribution of Prostate Specific Antigen in Men without clinical or Pathological Evidence of Prostate Cancer, J. Uro., 147, 837-840, 1992   DOI
5 Heijmink, S. W., van Moerkerk, H, Kiemeney, L. A., Witjes, J. A., Frauscher, F., Barentsz, J. O.: A Comparison of the Diagnostic Performance of Systematic Versus Ultrasound-Guided Biopsies of Prostate Cancer, Eur Radiol., 16, 927-938, 2006   DOI   ScienceOn
6 Onur, R., Littrup, P. J., Pontes, J. E., Bianco, F. J.: Contemporary Impact of Transrectal Ultrasound Lesions of Prostate Cancer Detection. J Urol., 172, 512-514, 2004   DOI   ScienceOn
7 Kuligowska, E., Barish, M. A., Fenlon, H. M., Blake, M.: Predictors of Prostate Carcinoma: Accuracy of Gray-Scale and Color Doppler US and Serum Markers, Radiology, 220, 757-764, 2001   DOI   ScienceOn
8 Partin, A. W., Oesterling, J. E.: The Clinical Usefulness of Prostate Specific Antigen Update, J. Uro., 152, 1358-1368, 1994   DOI
9 Jeon S. H., Lee, S. J., Lee, C, H., Chang, S. G., Kim, J. I., Lim, J. W.: Role of Color Doppler Sonography in Transrectal Ultrasound Guided Biopsy of Prostate, Korean J Urol, 42, 1291-1294, 2001
10 Wang, M. C., Valenzuela, L. A., Murphy, G. P., Chu, T. M.: Purification of a Human Prostate Specific Antigen Invest, J. Uro., 17, 159-163, 1979
11 Yuan, J. J., Coplen, D. E., Petros, J. A., Figen Shau, R. S., Ratliff, T. L., Smith, D. S. et al.: Effects of Rectal Examination, Prostate Massage, Ultrasonography and Needle Biopsy on Serum Prostate Specific Antigen Level, J. Uro., 147, 810-814, 1992   DOI
12 Watanabe, H., Holmes, J. H., Holm, H. H., Goldberg, B. B.: Diagnostic Ultrasound in Urology and Nephrology, 1st ed., Tokyo, Igaku Shoin Ltd,. 119-140, 1981
13 이승찬, 장훈, 정원일, 이상철, 김용태, 김원재: 전립선 용적에 따른 혈청 전립선특이항원치(PSA)의 변화, 충북의대학술지, 12, 2002
14 Cotran, S., Kumar, V., Collins, T.: Prostate in the Male Genital Tract. Robbins Pathologic Basis of Disease 6th Edition, Philadelphia: Saunders Company, 1025-1033, 1999
15 Freedland, J., Moul, J.: Prostate Specific Antigen Recurrence after Difinitive Therapy, J. Uro., 177, 1985-1991, 2007   DOI   ScienceOn