[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.3857/roj.2014.32.3.103

Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials

Kim, Jae Ho (Department of Radiation Oncology, Henry Ford Health System)
Jenrow, Kenneth A. (Department of Radiation Oncology, Henry Ford Health System)
Brown, Stephen L. (Department of Radiation Oncology, Henry Ford Health System)

Publication Information

Radiation Oncology Journal / v.32, no.3, 2014 , pp. 103-115 More about this Journal

Abstract

To summarize current knowledge regarding mechanisms of radiation-induced normal tissue injury and medical countermeasures available to reduce its severity. Advances in radiation delivery using megavoltage and intensity-modulated radiation therapy have permitted delivery of higher doses of radiation to well-defined tumor target tissues. Injury to critical normal tissues and organs, however, poses substantial risks in the curative treatment of cancers, especially when radiation is administered in combination with chemotherapy. The principal pathogenesis is initiated by depletion of tissue stem cells and progenitor cells and damage to vascular endothelial microvessels. Emerging concepts of radiation-induced normal tissue toxicity suggest that the recovery and repopulation of stromal stem cells remain chronically impaired by long-lived free radicals, reactive oxygen species, and pro-inflammatory cytokines/chemokines resulting in progressive damage after radiation exposure. Better understanding the mechanisms mediating interactions among excessive generation of reactive oxygen species, production of pro-inflammatory cytokines and activated macrophages, and role of bone marrow-derived progenitor and stem cells may provide novel insight on the pathogenesis of radiation-induced injury of tissues. Further understanding the molecular signaling pathways of cytokines and chemokines would reveal novel targets for protecting or mitigating radiation injury of tissues and organs.

Keywords

Radiation normal tissue injury; Protectors; Mitigators;

Citations & Related Records

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1	(2019) Stem cell research & therapy Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells / 10 (1) , 313
3	(2014) Plastic and reconstructive surgery. Global open Therapeutic Reversal of Radiotherapy Injury to Pro-fibrotic Dysfunctional Fibroblasts In Vitro Using Adipose-derived Stem Cells / 8 (3) , e2706
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1	(2014) Journal of radiation research and applied sciences Synergetic role of senna and fennel extracts as antioxidant, anti-inflammatory and anti-mutagenic agents in irradiated human blood lymphocyte cultures / 13 (1) , 191
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3	(2020) Cell death & disease Plasminogen is a master regulator and a potential drug candidate for the healing of radiation wounds / 11 (3) , 201
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10	(2020) Cur&emacr;us : medical knowledge for the world Comparing the Role of the p53 Gene and Telomerase Enzyme in ‘Accelerated Aging Due to Cancer’: A Literature Review / 12 (10) , e10794
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6	(2014) JNCI cancer spectrum Prostate Cancer Radiotherapy: Increased Biochemical Control and Late Toxicity in Men With Medication Allergies / 4 (6) , pkaa081
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7	(2014) 日本大腸肛門病學會雜誌 Journal of the Japan Society of Colo-Proctology Provisional Clinical Opinions for Radiation Therapy in Prefrail Elderly Colorectal Cancer Patients: Part One / 74 (7) , 413
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2	(2014) Acs applied bio materials Pharmacological Ascorbate Promotes the Tumor Radiosensitization of Au@Pd Nanoparticles with Simultaneous Protection of Normal Tissues / 4 (2) , 1843
6	(2014) Cancers Three-Dimensional Tumor Spheroids as a Tool for Reliable Investigation of Combined Gold Nanoparticle and Docetaxel Treatment / 13 (6) , 1465
8	(2014) Cancers Psychotherapy with Music Intervention Improves Anxiety, Depression and the Redox Status in Breast Cancer Patients Undergoing Radiotherapy: A Randomized Controlled Clinical Trial / 13 (8) , 1752
9	(2014) Molecules Radiation-Induced Metabolic Shifts in the Hepatic Parenchyma: Findings from 18F-FDG PET Imaging and Tissue NMR Metabolomics in a Mouse Model for Hepatocellular Carcinoma / 26 (9) , 2573
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20	(2021) Neurology Radiation-Induced Bilateral Oculomotor Nerve Palsy 20 Years After Radiation Treatment / 96 (20) , 955
7	(2021) Sn comprehensive clinical medicine Adverse Vascular Functional and Structural Changes Secondary to Breast Cancer and its Treatments with Adjuvant Therapy: a Systematic Review / 3 (7) , 1561
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21	(2021) Journal of clinical medicine Devastated Bladder Outlet in Pelvic Cancer Survivors: Issues on Surgical Reconstruction and Quality of Life / 10 (21) , 4920
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4	(2021) Radiation oncology journal : ROJ Clinical factors affecting the determination of radiotherapy-induced skin toxicity in breast cancer / 39 (4) , 315
1	(2014) Antioxidants Phytochemicals: Potential Therapeutic Modulators of Radiation Induced Signaling Pathways / 11 (1) , 49