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Results of Three-Dimensional Conformal Radiation Therapy for the Treatment of a Solitary Sternal Relapse of Breast Cancer  

Kim, Hae-Young (Departments of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Huh, Seung-Jae (Departments of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Park, Won (Departments of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Choi, Do-Ho (Departments of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Kang, Min-Kyu (Departments of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Yang, Jung-Hyun (Departments of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Nam, Seok-Jin (Departments of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Im, Young-Hyuck (Departments of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
Publication Information
Radiation Oncology Journal / v.26, no.2, 2008 , pp. 91-95 More about this Journal
Abstract
Purpose: To evaluate the response and survival rate after three-dimensional conformal radiation therapy(3D-CRT) of patients with a solitary sternal relapse of breast cancer. Materials and Methods: Seventeen patients between May 1996 and June 2005 were evaluated with the salvage 3D-CRT treatment of a solitary sternal relapse of breast cancer. The treatment fields included the gross tumor volume with 2 cm margins. The total radiation dose was $35.0{\sim}61.5$ Gy(biologic effective dose of $43.7{\sim}76.9Gy_{10}$ using an $\alpha/\beta$ ratio of 10 Gy), with a daily dose of $1.8{\sim}3.0$ Gy. The tumor response was evaluated by the change in maximum tumor size via follow up CT scans $1{\sim}3$ months after the completion of treatment. Results: An objective tumor response was achieved in all patients, with a complete response in 5 patients and a partial response in 12 patients. The 5-year overall survival rate was 51.9%(median survival time: 27 months), and the most important factor affecting overall survival was the disease-free interval(interval from primary surgery of breast cancer to the development of sternal metastasis): The 5-year overall survival rate was 61.8% for patients with a disease-free interval ${\geq}12$ months and 0.0% for patients with disease-free interval <12 months(p=0.03). Conclusion: The response to 3D-CRT was good in patients with solitary sternal relapse of breast cancer. Particularly, patients with long disease-free interval from primary surgery survived significantly longer than patients with short disease-free interval from primary surgery.
Keywords
Solitary sternal relapse; Three-dimensional conformal radiotherapy; Breast cancer;
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