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A Comparison of Clinical Outcomes for Breast-conserving Treatment and Mastectomy for Early Breast Cancer  

Noh, Jae-Myoung (Departments of Radiation Oncology, Sungkyunkwan University School of Medicine)
Park, Won (Departments of Radiation Oncology, Sungkyunkwan University School of Medicine)
Huh, Seung-Jae (Departments of Radiation Oncology, Sungkyunkwan University School of Medicine)
Choi, Doo-Ho (Departments of Radiation Oncology, Sungkyunkwan University School of Medicine)
Yang, Jung-Hyun (Departments of Surgery, Sungkyunkwan University School of Medicine)
Nam, Seok-Jin (Departments of Surgery, Sungkyunkwan University School of Medicine)
Kim, Jeong-Han (Departments of Surgery, Sungkyunkwan University School of Medicine)
Im, Young-Hyuck (Departments of Hematology-oncology, Sungkyunkwan University School of Medicine)
Ahn, Jin-Seok (Departments of Hematology-oncology, Sungkyunkwan University School of Medicine)
Publication Information
Radiation Oncology Journal / v.26, no.1, 2008 , pp. 10-16 More about this Journal
Abstract
Purpose: To compare the treatment outcomes and to analyze prognostic factors between the use of a breast-conserving treatment(BCT) and a mastectomy for early stage breast cancer. Materials and Methods: We retrospectively reviewed 1,200 patients with pathological stage T1-2N0 breast cancer who received surgery between September 1994 and December 2002 at Samsung Medical Center. We compared the patient characteristics and treatment outcomes between the two treatment groups. Results: Among the 1,174 eligible patients, 601(51.2%) patients received a BCT and the remaining 573(48.8%) patients received a mastectomy. The mastectomy group of patients had significantly more cases with a larger tumor size, multicentricity, extensive intraductal component, and estrogen- and progester-one-receptor negativity. The ten-year overall survival rates(OS) of the BCT and mastectomy groups were 91.96% and 91.01%, respectively(p=0.1274). The ten-year disease-free survival rates(DFS) were 80.48% for the BCT group of patients and 84.95% for the mastectomy group of patients, respectively(p=0.8795). Conclusion: Our study shows some differences in patient characteristics between the two treatment groups. However, these differences did not result in significant survival differences.
Keywords
Breast cancer; Breast-conserving surgery; Mastectomy;
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