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Prediction of Prognosis to Concurrent Chemo-Radiotherapy by Standardized Uptake Value of $2-[18^F]$ Fluovo-2-Deoxy-D-Glucose for Nasopharyngeal Carcinomas  

Lee Sang-wook (Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center)
Im Ki Chun (Department of Nuclear Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Nam Soon Yuhl (Department of Otorhinolaryngology, University of Ulsan College of Medicine, Asan Medical Center)
Kim Jae Seung (Department of Nuclear Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Choi Eun Kyung (Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center)
Ahn Seung Do (Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center)
Shin Seong Soo (Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center)
Ryu Jin Sook (Department of Nuclear Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Kim Sang Yoon (Department of Otorhinolaryngology, University of Ulsan College of Medicine, Asan Medical Center)
Lee Bong-Jae (Department of Otorhinolaryngology, University of Ulsan College of Medicine, Asan Medical Center)
Choi Seung-Ho (Department of Otorhinolaryngology, University of Ulsan College of Medicine, Asan Medical Center)
Kim Sung-Bae (Department of Oncology, University of Ulsan College of Medicine, Asan Medical Center)
Moon Dae Hyuk (Department of Nuclear Medicine, University of Ulsan College of Medicine, Asan Medical Center)
Publication Information
Radiation Oncology Journal / v.23, no.1, 2005 , pp. 9-16 More about this Journal
Abstract
Purpose : To prospectively evaluate the use of positron emission tomography with the glucose analog fluoro-deoxyglucose (FDG-PET) to deoxyglucose (FDG-PET) to predict disease-free survival (DFS) after concurrent chemo-radiotherapy (CCRT) in patients with non-disseminated nasopharyngeal carcinoma (NPC). Materials and Methods : We studied 41 patients with non-disseminated NPC scheduled to undergo platinum-based CCRT were eligible for this study. Patients were studied by FDG-PET prior to the CCRT. FDG uptake of tumors were measured with the maximal standardized uptake value (SUV). Results : Complete response rate was $100\%$. In ten patients who presented with any component of treatment failure, the median $SUV_{max}$ was 8.55 (range: $2.49\~14.81$) in any component of failure and the median $SUV_{max}$ was 5.48 (range: $2.31\~26.07$) In the remaining patients without any such failure. Patients having tumors with high FDG uptake had a significantly lower 3-year DFS ($51\%\;{\nu}91\%$, p=0.0070) compared with patients having low uptake tumors. Conclusion : FDG uptake, as measured by the SUV, has potential value in predicting DFS in NPC treated by CCRT, High FDG uptake may be a useful parameter for Identifying patients requiring more aggressive treatment approaches.
Keywords
Nasopharyngeal carcinoma; FDG-PET; CCRT;
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