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http://dx.doi.org/10.14480/JM.2017.15.4.244

Effect of Paecilomyces tenuipes extract on angiogenesis in prostate cancer cells  

Choi, Young-Jin (Division of Food Bioscience, Konkuk University)
Fan, Meiqi (Division of Food Bioscience, Konkuk University)
Choi, Eun-Ju (Department of Physical Education, Daegu Catholic University)
Kim, Eun-kyung (Division of Food Bioscience, Konkuk University)
Publication Information
Journal of Mushroom / v.15, no.4, 2017 , pp. 244-248 More about this Journal
Abstract
In this study, the inhibitory effect of Paecilomyces tenuipes extract on PSA and angiogenesis-related factor expression levels were investigated in human prostate cancer cells, LNCaP. P. tenuipes extract significantly inhibited PSA expression in a dose-dependent manner. We also investigated the inhibitory effect of P. tenuipes extract on the expression of angiogenesis-related genes including VEGF, MMP-2, MMP-9, TIMP-1, and TIMP-2. P. tenuipes extract significantly down-regulated the expression of MMP-2 and MMP-9 in a dose-dependent manner. On the contrary, P. tenuipes increased the expression of TIMP-1 and TIMP-2. Our findings indicate that P. tenuipes exhibits an inhibitory effect on angiogenesis in human prostate cancer cells.
Keywords
Angiogenesis; LNCaP; Paecilomyces tenuipes; Prostate cancer;
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