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http://dx.doi.org/10.14480/JM.2017.15.3.124

Inhibitory effects of Sanghwang mushrooms, Phellinus linteus strains and Phellinus baumii, on platelet aggregation  

Kang, Hee-Wan (Department of Horticultural Life Science, Hankyong National University)
Rhee, Man-Hee (College of Veterinary Medicine, Kyungpook National University)
Yeo, Woon-Hyung (KT&G Central Research Institute)
Publication Information
Journal of Mushroom / v.15, no.3, 2017 , pp. 124-128 More about this Journal
Abstract
The fruiting bodies of Sanghwang mushrooms, Phellinus linteus HN1009K (PLH) and Phellinus linteus (Korea Sanghwang, PLK), and Phellinus baumii (Jangsu Sangwhang, PB), were extracted with 70% methanol. The methanolic extracts of different concentrations ($5-200{\mu}g/ml$) showed inhibitory effects of 20-95% on plated aggregation induced by collagen (2.5 ug/ml), ADP (10 uM), and thrombin (0.1 U/ml). The PLH, PLK, and PB extracts (200 ug/ml) reduced ATP release from ADP-activated platelets by 50-60%. These results suggest that the methanolic extracts from Sanghwang mushrooms inhibit platelet aggregation.
Keywords
Anti-platelet Aggregation; ATP release; Methanolic extracts; Sanghwang mushrooms;
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