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http://dx.doi.org/10.14480/JM.2016.14.4.155

Inhibitory effect of Panax ginseng and Pleurotus osteratus complex on expression of cytokine genes induced by extract of Dermatophagoides pteronissinus in human monocytic THP-1 and EoL-1 cells  

Park, Kyeong Hun (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA)
Lee, Eun Suk (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA)
Jin, Yong Ik (Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration)
Myung, Kyung Sun (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA)
Park, Hong Woo (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA)
Park, Chun Geon (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA)
Kong, Won Sik (Mushroom Research Division, National Institute of Horticultural and Herbal Science, RDA)
Kim, Young Ock (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA)
Publication Information
Journal of Mushroom / v.14, no.4, 2016 , pp. 155-161 More about this Journal
Abstract
A recent study reported that Pleurotus ostreatus has the potential to be used as a ${\beta}-glucan-based$ cream for supportive complementary therapy of atopic dermatitis. KH054 is a new herbal prescription consisting of P. ostreatus and Panax ginseng. The effects of atopic dermatitis-induced materials on the expression of cytokine genes in human monocytes (THP-1, EoL- 1) have been examined. Some reports demonstrated that P. ginseng augments the activity of natural killer cells, which plays an important role in innate immunity against infection and tumor development. Monocyte chemotactic protein 1 (MCP-1), interleukin (IL)-6, and IL-8 have important roles in mediating the infiltration of various cells into the skin of atopic dermatitis and psoriasis. The present study investigated whether KH054 on induced IL-6, IL-8, and MCP-1 secretion by house dust mite (Dermatophagoides pteronissinus) in THP-1 (human acute monocytic leukemia) and EoL-1(Human eosinophilic leukemia) cell. D. pteronissinus functions in the pathogenesis of allergic diseases, including atopic dermatitis and asthma. The inhibitory effect of KH054 on the induction of IL-6, IL-8, and MCP-1 secretion by D. pteronissinus extract in THP-1 and EoL-1 cells was examined. KH054 potently suppressed the elevated production of IL-6 and IL-8 induced by D. pteronissinus treatment in THP-1 and EoL-1 cells. Based on the present results, KH054 may be useful for developing functional foods to treat atopic dermatitis.
Keywords
Monocyte chemoattractant protein-1; Interleukin-6; Interleukin-8; Pleurotus ostreatus; Panax ginseng; Dermatophagoides pteronissinus;
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