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http://dx.doi.org/10.14480/JM.2015.13.3.170

Inhibitory effect of mushrooms extract on TNF-α/INF-γ induced-cytokine in human keratinocytes, HaCaT  

Choi, Eun-Ju (Division of Sport Science, College of Science and Technology, Konkuk University)
Kim, Eun-Kyung (Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University)
Ji, Yong-Seok (Department of Physical Education, Cheongju University)
Lee, Chang-Jin (Division of Sport Science, College of Science and Technology, Konkuk University)
Publication Information
Journal of Mushroom / v.13, no.3, 2015 , pp. 170-174 More about this Journal
Abstract
Mushroom is known for anti-inflammatory and anti-oxidative potential. This study provides evidence that the inhibitory effect of mushroom on the expression of pro-inflammatory cytokines in human keratinocytes, HaCaT cells. To define the underlying mechanisms of action, tumor necrosis factor${\alpha}$/$IFN{\gamma}$-activated human keratinocytes model was used. Mushroom significantly inhibited the expression of cytokines in HaCaT cells. Taken together, the results demonstrate that mushroom inhibited inflammtion, suggesting that mushroom (DW extract: Grifola frondosa Cordyceps militaris), (Ethanol extract: Ganoderma lucidum, Lentinus edodes, Cordyceps militaris, Flammulina velutipes) might be a candidate for the treatment of skin inflammation.
Keywords
Cytokine; HaCaT cell; Inflammation; Mushroom; TNF-${\alpha}$;
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Times Cited By KSCI : 4  (Citation Analysis)
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