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http://dx.doi.org/10.14407/jrp.2015.40.3.187

CHANGING OF RGS TRANSCRIPTS LEVELS BY LOW-DOSE-RATE IONIZING RADIATION IN MOUSE TESTIS  

Kim, Tae-Hwan (Laboratory of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University)
Baik, Ji Sue (Research Center, Dongnam Institute of Radiological & Medical Sciences)
Heo, Kyu (Research Center, Dongnam Institute of Radiological & Medical Sciences)
Kim, Joong Sun (Research Center, Dongnam Institute of Radiological & Medical Sciences)
Lee, Ki Ja (Laboratory of Veterinary Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University)
Rhee, Man Hee (Laboratory of Veterinary Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University)
Kim, Sung Dae (Research Center, Dongnam Institute of Radiological & Medical Sciences)
Publication Information
Journal of Radiation Protection and Research / v.40, no.3, 2015 , pp. 187-193 More about this Journal
Abstract
Deleterious effects of high dose radiation exposure with high-dose-rate are unarguable, but they are still controversial in low-dose-rate. The regulator of G-protein signaling (RGS) is a negative regulator of G protein-coupled receptor (GPCR) signaling. In addition, it is reported that irradiation stress led to GPCR-mediated mitogen-activated protein kinase (MAPK) and phosphotidylinositol 3-kinase (PI3-k) signaling. The RGS mRNA expression profiles by whole body radiation with low-dose-rate has not yet been explored. In the present study, we, therefore, examined which RGS was modulated by the whole body radiation with low-dose-rate ($3.49mGy{\cdot}h^{-1}$). Among 16 RGS expression tested, RGS6, RGS13 and RGS16 mRNA were down-regulated by low-dose-rate irradiation. This is the first report that whole body radiation with low-dose-rate can modulate the different RGS expression levels. These results are expected to reveal the potential target and/or the biomarker proteins associated with male testis toxicity induced by low-dose-rate irradiation, which might contribute to understanding the mechanism beyond the testis toxicity.
Keywords
Gamma radiation; Low-dose-rate; RGS; Testis;
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