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Radioprotective Effect of Extracts from Plants Indigenous to Korea  

Kang Kyoung-Ah (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Zhang Rui (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Chae Sung-Wook (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Piao Mei Jing (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Shin Tae-Kyun (Department of Veterinary Medicine, Cheju National University)
Lee Nam-Ho (Department of Chemistry, College of Natural Sciences, Cheju National University)
Park Jae-Woo (Department of Nuclear and Energy Engineering, Cheju National University)
Hyun Jin-Won (Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University)
Publication Information
Journal of Radiation Protection and Research / v.31, no.3, 2006 , pp. 115-122 More about this Journal
Abstract
We have screened the cytoprotective effect on $\gamma$-ray radiation induced oxidative stress from eighteen Korean plant extracts. Querus salicina, Clerodendron trichotomum, Lamium amplexicaule, Lozoste lancifolia and Malus baccata were found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). As a result, extracts of these plants reduced cell death of Chinese hamster lung fibroblast (V79-4) cells induced by $H_2O_2$ treatment. In addition, these extracts protected cell death of V79-4 cells damaged by $\gamma$-ray radiation. In addition, these extracts scavenged ROS generated by radiation. Taken together, the results suggest that Quercus salicina, Clerodendron trichotomum, Lamium amplexicaule, Lozoste lancifolia and Malus baccata protect V79-4 cells against oxidative damage by radiation through scavenging ROS.
Keywords
${\gamma}$-ray radiation; oxidative stress; reactive oxygen species;
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