Browse > Article

Individual Variation of Radiation Adaptive Responses in Patients Undergoing Imaging Studies Using $^{99m}Tc$ Labeled Radiopharmaceuticals  

Li, Ming-Hao (Department of Nuclear Medicine, Chonnam National University Medical School)
Bom, Hee-Seung (Department of Nuclear Medicine, Chonnam National University Medical School)
Kwon, An-Sung (Department of Nuclear Medicine, Chonnam National University Medical School)
Kim, Young-Ho (Department of Nuclear Medicine, Chonnam National University Medical School)
Kim, Ji-Yeul (Department of Nuclear Medicine, Chonnam National University Medical School)
Publication Information
Journal of Radiation Protection and Research / v.28, no.2, 2003 , pp. 117-125 More about this Journal
Abstract
It was reported that radiopharamaceuticals induced radiation adaptive response (RAR) in patients undergoing nuclear medicine imaging studies. Individual variations of RAR were not studied well. The purpose of this study was to evaluate individual variation of RAR in patients undergoing nuclear medicine imaging studies. Peripheral lymphocytes were collected from 23 patients undergoing $^{99m}Tc-diethylenetriamine$ pentaacetic acid $(^{99m}Tc-DTPA)$ renal scintigraphy, 18 patients undergoing $^{99m}Tc-methylene$ diphosphonate $(^{99m}Tc-MDP)$ bone scintigraphy and 21 patients undergoing $^{99m}Tc-tetrofosmin\;(^{99m}Tc-TF)$ scintigraphy were collected before and 4 hours after injection of radiopharmaceuticals. The lymphocytes were exposed to challenge dose of 2 Gy gamma rays using a cell irradiator. Numbers of ring-form (R) and dicentric (D) chromosomes were counted under the light microscope. and used to calculate the frequency of chromosomal aberration [Ydr=(D+R)/total number of counted lymphocytes]. Adaptation index (k) was defined 3s ratio of Ydr in conditioned lymphocytes over Ydr in unconditioned lymphocytes. Coefficients of variance of k in $^{99m}Tc-DTPA,\;^{99m}Tc-MDP\;and\;^{99m}Tc-TF$ were 35%, 34% and 21%, respectively k was not dependent upon age, sex, and underlying diseases. There was a wide variation of RAR induced by radiopharmaceuticals among patients undergoing nuclear medicine procedures. It remains to be determined for causes of such variation.
Keywords
radiation; radiation; radiopharmaceuticals; adaptive response; individual variation; nuclear medicine imaging;
Citations & Related Records
연도 인용수 순위
  • Reference
1 M. Bauchinger, E. Schmid, H. Braselman, U. Nahrstedt. Absence of an adaptive response to low-level radiation from tritiated thymidine and X-rays in lymphocytes of two individuals examined in serial experiment. Mutation Research 227:103-107(1989)
2 ZQ. Wang, S. Saigusa, MS. Sasaki. Adaptive response to chromosome damage in cultured human lymphocytes primed with low doses of X-rays. Mutation Research 246:179-186(1991)
3 KT. Kelsey, A. Memisoglu, D. Frekel, HL. Liber. Human lymphocytes exposed to low doses of X-rays are less susceptible to radiation-induced mutagenesis. Mutation Research 263:197-201 (1991)
4 JD. Shadley, V. Afzal, S. Wolff. Characterization of the adaptive response to ionizing radiation by low doses of X-rays to human lymphocytes. Radiat Res 111: 511-7(1987)
5 EK. Khandogina, GR. Mutovin, SV. Zverva, AV. Antipov, AP. Akifyev. Adaptive response In irradiated human lymphocytes: radiobiological and genetical aspects. Mutation Research 251:181-186(1991)
6 K. Sankaranarayanan, A. Duyn, M). Loos, AT. Natarajan. Adaptive response of human lymphocytes to low-level radiation from radioisotopes or Xrrays, Mutation Research 211:7-12(1989)
7 NJ. Ryabchenko, MM. Antoshchina, EV. Fesenko, TI. Ivanova, TV. Kondrashova, A. Valentina, et al. Cytogenetic adaptive response in cultured human lymphocytes: dependence on the time of exposure to adapting and challenging doses of $\gamma$-rays. Mutation Research 418:7-19(1998)
8 HS. Bom, MH. Li, JJ. Min, AS. Kwon, JY. Kim. Comparison of Radiation adaptive Responses in Peripheral Lymphocytes of Patients Undergoing T-99m MDP and T-99m DTPA Scintigraphies Korean J Nucl Med 34:252-259 (2000)
9 M. Sasiadk, M. Paprocka-Borowicz. Correlation between the adaptive response and individual sensitivity to monoepoxybutene in in vitro experiments on human lymphocytes. Mutation Research 390:239-243(1997)
10 JJ. Min. HS. Born. Induction of radiation adaptive response in lymphocytes of patients undergoing bone scintigraphy. Korean J Nucl Mcd 33:172-177(1999)
11 G. Joksic, M. Nikolic, V. Spasolevic-Tisma. Radiosensitivity of different aged human lymphocytes following electron irradiation In vitro. Neoplasma 44:117-121(1997)
12 A. Bosi, G. Olivieri. Variability of the adaptive response to ionizing radiations in humans. Mutation Research 211:13-17(1989)
13 G. Olivieri, J. Bodycote, S. Wolff. Adaptive response of human lymphocytes to low concentrations of radiations of radioactive thymidine. Science 223:594-597(1984)
14 JD. Shadley, JK. Wieneke. Induction of the adaptive response by X-ray is dependent on radiation intensity. Int J Radiat Biol 56:107-118(1989)
15 BJS. Sanderson, AA. Morley. Exposure of human lymphocytes - to ionizing radiation reduces mutagenesis by subsequent ionizing radiation. Mutation Research 164:347-351(1986)
16 A Wojcik, K. Bonk, WU Muller, C. Streffer, U. Weissenborn, G. Obe. Absence of adaptive response to low doses of X-rays In preimplantation embryos and spleen lymphocytes of an inbred mouse strain as compared to human peripheral lymphocytes: a cytogenetic study. Int J Radiat Biol 62:177-186(1992)
17 JH. Youngblom, JK. Wieneke, S. Wolff. Inhibition of the adaptive response of human lymphocytes to very low doses of ionizing radiation by the protein synthesis inhibitor cycloheximide. Mutation Research 227:257-261(1989)
18 BZ. Vijayalami, TS. Deahl. ML. Meltz. Variability in adaptive response to low dose radiation In human blood lymphocytes: consistent results from chromosome aberrations and micronucli. Mutation Research 348:45-50(1995)
19 MA. Monsieurs, HM. Thierens, AM. Vral, C. Van De Wiele, D. Ridder LI, RA. Dierckx. Adaptive response in patients treated with 1-131. J Nucl Med 41:17-22(2000)
20 V. Pretazzoli, B. Salone, A Bosi, G. Olivieri. Variability of G2 checkpoint sensitivity to low doses of X-ravs (2 cGy): correlation with G2 chromatid aberrations but no with an adaptive response. Mutagenesis 15:531-535(2000)
21 Y. Bai, D. Chen. Accumulative effect of two low doses of irradiation in inducing an adaptive response in human lymphocytes. Mutation Research 302:191-196(1993)
22 JD. Shadley, G. Dai. Cytogenetic and survival adaptive responses in G1 phase human lymphocytes. Mutation Research 265:273-281 (1992)