Browse > Article
http://dx.doi.org/10.24986/anxmod.2018.14.2.63

Recent Advances on Resting State Functional Abnormalities of the Default Mode Network in Social Anxiety Disorder  

Yoon, Hyung-Jun (Department of Psychiatry, Chosun University College of Medicine)
Seo, Eun Hyun (Premedical Science, Chosun University College of Medicine)
Kim, Seung-Gon (Department of Psychiatry, Chosun University College of Medicine)
Publication Information
Anxiety and mood / v.14, no.2, 2018 , pp. 63-70 More about this Journal
Abstract
It has been suggested that aberrant self-referential processing (SRP) is one of the important components of the explanatory models of social anxiety disorder (SAD). The default mode network (DMN), which reflects intrinsic brain functions, is known to play a critical role in SRP. Recently, resting state functional magnetic resonance imaging (fMRI) research on the functional connectivity in the brain network has gained greater attention as a tool to elucidate the neurobiological basis of various psychiatric disorders. We reviewed resting state fMRI studies that investigated the resting state functional connectivity (RSFC) of the DMN in SAD. Despite of the heterogeneity of the analytic methods and occasional negative findings, most studies consistently reported abnormalities of RSFC within the DMN, suggesting that the DMN may be significant neural correlates of aberrant SRP in SAD. Also, changes in RSFC of the DMN are associated with clinical improvements of therapeutic interventions. Moreover, emerging findings provide the basis for potential use of RSFC as a complementary method in diagnosis of SAD. Ongoing and future research to investigate RSFC of the DMN could broaden our understanding regarding the neurobiological basis of SAD, and contribute to the development of novel treatments for SAD.
Keywords
Social anxiety disorder; Default mode network; Resting state functional connectivity; Self-referential processing;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005;62:593-602.   DOI
2 Sadock BJ, Sadock VA, Ruiz P. Kaplan & Sadock's synopsis of psychiatry:behavioral sciences/clinical psychiatry. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia; London, 2015.
3 American Psychiatric Association. American Psychiatric Association. DSM-5 Task Force. Diagnostic and statistical manual of mental disorders: DSM-5. American Psychiatric Association, Washington, D.C., 2013.
4 Stein MB, Kean YM. Disability and quality of life in social phobia:epidemiologic findings. Am J Psychiatry 2000;157:1606-1613.   DOI
5 Freitas-Ferrari MC, Hallak JE, Trzesniak C, Filho AS, Machadode-Sousa JP, Chagas MH, et al. Neuroimaging in social anxiety disorder: a systematic review of the literature. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:565-580.   DOI
6 Beckmann CF, DeLuca M, Devlin JT, Smith SM. Investigations into resting-state connectivity using independent component analysis. Philos Trans R Soc Lond B Biol Sci 2005;360:1001-1013.   DOI
7 Lee MH, Smyser CD, Shimony JS. Resting-state fMRI: a review of methods and clinical applications. AJNR Am J Neuroradiol 2013;34:1866-1872.   DOI
8 Wang L, Song M, Jiang T, Zhang Y, Yu C. Regional homogeneity of the resting-state brain activity correlates with individual intelligence. Neurosci Lett 2011;488:275-278.   DOI
9 Zang Y, Jiang T, Lu Y, He Y, Tian L. Regional homogeneity approach to fMRI data analysis. Neuroimage 2004;22:394-400.   DOI
10 Zang YF, He Y, Zhu CZ, Cao QJ, Sui MQ, Liang M, et al. Altered baseline brain activity in children with ADHD revealed by restingstate functional MRI. Brain Dev 2007;29:83-91.   DOI
11 Raichle ME, Snyder AZ. A default mode of brain function: a brief history of an evolving idea. Neuroimage 2007;37:1083-1090.   DOI
12 Bruhl AB, Delsignore A, Komossa K, Weidt S. Neuroimaging in social anxiety disorder-a meta-analytic review resulting in a new neurofunctional model. Neurosci Biobehav Rev 2014;47:260-280.   DOI
13 Bullmore E, Sporns O. Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 2009;10:186-198.   DOI
14 Zuo X, Ehmke R, Mennes M, Imperati D, Castellanos FX, Sporns O, et al. Network centrality in the human functional connectome. Cereb Cortex 2012;22:1862-1875.   DOI
15 Anderson JS, Nielsen JA, Froehlich AL, DuBray MB, Druzgal TJ, Cariello AN, et al. Functional connectivity magnetic resonance imaging classification of autism. Brain 2011;134:3742-3754.   DOI
16 Liu F, Guo W, Fouche JP, Wang Y, Wang W, Ding J, et al. Multivariate classification of social anxiety disorder using whole brain functional connectivity. Brain Struct Funct 2015;220:101-115.   DOI
17 Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci U S A 2005;102:9673-9678.   DOI
18 Gentili C, Gobbini MI, Ricciardi E, Vanello N, Pietrini P, Haxby JV, et al. Differential modulation of neural activity throughout the distributed neural system for face perception in patients with Social Phobia and healthy subjects. Brain Res Bull 2008;77:286-292.   DOI
19 Sareen J, Campbell DW, Leslie WD, Malisza KL, Stein MB, Paulus MP, et al. Striatal function in generalized social phobia: a functional magnetic resonance imaging study. Biol Psychiatry 2007;61:396-404.   DOI
20 Tillfors M, Furmark T, Marteinsdottir I, Fredrikson M. Cerebral blood flow during anticipation of public speaking in social phobia: a PET study. Biol Psychiatry 2002;52:1113-1119.   DOI
21 Chou YH, Panych LP, Dickey CC, Petrella JR, Chen NK. Investigation of long-term reproducibility of intrinsic connectivity network mapping: a resting-state fMRI study. AJNR Am J Neuroradiol 2012;33:833-838.   DOI
22 Woodward ND, Cascio CJ. Resting-state functional connectivity in psychiatric disorders. JAMA Psychiatry 2015;72:743-744.   DOI
23 Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates. Brain 2006;129:564-583.   DOI
24 Hu ML, Zong XF, Mann JJ, Zheng JJ, Liao YH, Li ZC, et al. A review of the functional and anatomical default mode network in schizophrenia. Neurosci Bull 2017;33:73-84.   DOI
25 Gaebler M, Daniels JK, Lamke JP, Fydrich T, Walter H. Behavioural and neural correlates of self-focused emotion regulation in social anxiety disorder. J Psychiatry Neurosci 2014;39:249-258.   DOI
26 Guo W, Liu F, Zhang J, Zhang Z, Yu L, Liu J, et al. Abnormal default-mode network homogeneity in first-episode, drug-naive major depressive disorder. PLoS One 2014;9:e91102.   DOI
27 Hu ML, Zong XF, Mann JJ, Zheng JJ, Liao YH, Li ZC, et al. A Review of the Functional and Anatomical Default Mode Network in Schizophrenia. Neurosci Bull 2017;33:73-84.   DOI
28 Peterson A, Thome J, Frewen P, Lanius RA. Resting-state neuroimaging studies: a new way of identifying differences and similarities among the anxiety disorders? Can J Psychiatry 2014;59:294-300.   DOI
29 Gimenez M, Ortiz H, Soriano-Mas C, Lopez-Sola M, Farre M, Deus J, et al. Functional effects of chronic paroxetine versus placebo on the fear, stress and anxiety brain circuit in Social Anxiety Disorder:initial validation of an imaging protocol for drug discovery. Eur Neuropsychopharmacol 2014;24:105-116.   DOI
30 Badhwar A, Tam A, Dansereau C, Orban P, Hoffstaedter F, Bellec P. Resting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis. Alzheimers Dement (Amst) 2017;8:73-85.
31 Jazaieri H, Morrison AS, Goldin PR, Gross JJ. The role of emotion and emotion regulation in social anxiety disorder. Curr Psychiatry Rep 2015;17:531.   DOI
32 Fenigstein A, Scheier MF, Buss AH. Public and private self-consciousness:assessment and theory. J Consult Clin Psychol 1975;43:522-527.   DOI
33 Blair K, Geraci M, Devido J, McCaffrey D, Chen G, Vythilingam M, et al. Neural response to self-and other referential praise and criticism in generalized social phobia. Arch Gen Psychiatry 2008;65:1176-1184.   DOI
34 Goldin P, Ramel W, Gross J. Mindfulness meditation training and self-referential processing in social anxiety disorder: Behavioral and Neural Effects. J Cogn Psychother 2009;23:242-257.   DOI
35 Yoon HJ, Kim JS, Shin YB, Choi SH, Lee SK, Kim JJ. Neural activity during self-referential working memory and the underlying role of the amygdala in social anxiety disorder. Neurosci Lett 2016;627:139-147.   DOI
36 Stein DJ. Social anxiety disorder and the psychobiology of self-consciousness. Front Hum Neurosci 2015;9:489.
37 van den Heuvel MP, Hulshiff Pol HE. Exploring the brain network:a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol 2010;20:519-534.   DOI
38 Sui J, Pearlson G, Caprihan A, Adali T, Kiehl KA, Liu J, et al. Discriminating schizophrenia and bipolar disorder by fusing fMRI and DTI in a multimodal CCA+ joint ICA model. Neuroimage 2011;57:839-855.   DOI
39 Yuan M, Zhu H, Qiu C, Meng Y, Zhang Y, Ren Z, et al. Altered regional and integrated resting-state brain activity in general social anxiety disorder patients before and after group cognitive behavior therapy. Psychiatry Res 2018;272:30-37.   DOI
40 Kirino E, Tanaka S, Fukuta M, Inami R, Arai H, Inoue R, et al. Simultaneous resting-state functional MRI and electroencephalography recordings of functional connectivity in patients with schizophrenia. Psychiatry Clin Neurosci 2017;71:262-270.   DOI
41 Yang H, Liu J, Sui J, Pearlson G, Calhoun VD. A hybrid machine learning method for fusing fMRI and genetic data: combining both improves classification of schizophrenia. Front Hum Neurosci 2010;4:192.
42 Andrews-Hanna JR, Smallwood J, Spreng RN. The default network and self-generated thought: component processes, dynamic control, and clinical relevance. Ann N Y Acad Sci 2014;1316:29-52.   DOI
43 Gusnard DA, Raichle ME. Searching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci 2001;2:685-694.   DOI
44 Fransson P. Spontaneous low-frequency BOLD signal fluctuations:An fMRI investigation of the resting-state default mode of brain function hypothesis. Hum Brain Mapp 2005;26:15-29.   DOI
45 Mason MF, Norton MI, Van Horn JD, Wegner DM, Grafton ST, Macrae CN. Wandering minds: the default network and stimulusindependent thought. Science 2007;315:393-395.   DOI
46 Roth DA, Heimberg RG. Cognitive-behavioral models of social anxiety disorder. Psychiatr Clin North Am 2001;24:753-771.   DOI
47 Spurr JM, Stopa L. Self-focused attention in social phobia and social anxiety. Clin Psychol Rev 2002;22:947-975.   DOI
48 Clark DM, Wells A. Social phobia: diagnosis, assessment, and treatment. In: Heimberg RG, Liebowitz, M.R., Hope D.A., Schneier F.R. (ed.), A Cognitive Model of Social Phobia. Guilford, New York;1995. p.69-93.
49 Rapee RM, Heimberg RG. A cognitive-behavioral model of anxiety in social phobia. Behav Res Ther 1997;35:741-756.   DOI
50 Hofmann SG, Moscovitch DA, Kim HJ, Taylor AN. Changes in selfperception during treatment of social phobia. J Consult Clin Psychol 2004;72:588-596.   DOI
51 Hahn A, Wadsak W, Windischberger C, Baldinger P, Hoflich AS, Losak J, et al. Differential modulation of the default mode network via serotonin-1A receptors. Proc Natl Acad Sci U S A 2012;109:2619-2624.   DOI
52 Gusnard DA, Akbudak E, Shulman GL, Raichle ME. Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci U S A 2001;98:4259-4264.   DOI
53 Frick A, Ahs F, Engman J, Jonasson M, Alaie I, Bjorkstrand J, et al. Serotonin Synthesis and Reuptake in Social Anxiety Disorder: A Positron Emission Tomography Study. JAMA Psychiatry 2015;72:794-802.   DOI
54 Kim YK, Yoon HK. Common and distinct brain networks underlying panic and social anxiety disorders. Prog Neuropsychopharmacol Biol Psychiatry 2018;80:115-122.   DOI
55 Saulin A, Savli M, Lanzenberger R. Serotonin and molecular neuroimaging in humans using PET. Amino Acids 2012;42:2039-2057.   DOI
56 Michelsen KA, Schmitz C, Steinbusch HW. The dorsal raphe nucleus--from silver stainings to a role in depression. Brain Res Rev 2007;55:329-342.   DOI
57 Ding J, Chen H, Qiu C, Liao W, Warwick JM, Duan X, et al. Disrupted functional connectivity in social anxiety disorder: a restingstate fMRI study. Magn Reson Imaging 2011;29:701-711.   DOI
58 Qiu C, Liao W, Ding J, Feng Y, Zhu C, Nie X, et al. Regional homogeneity changes in social anxiety disorder: a resting-state fMRI study. Psychiatry Res 2011;194:47-53.   DOI
59 Liu F, Zhu C, Wang Y, Guo W, Li M, Wang W, et al. Disrupted cortical hubs in functional brain networks in social anxiety disorder. Clin Neurophysiol 2015;126:1711-1716.   DOI
60 Qiu C, Feng Y, Meng Y, Liao W, Huang X, Lui S, et al. Analysis of Altered Baseline Brain Activity in Drug-Naive Adult Patients with Social Anxiety Disorder Using Resting-State Functional MRI. Psychiatry Investig 2015;12:372-380.   DOI
61 Geiger MJ, Domschke K, Ipser J, Hattingh C, Baldwin DS, Lochner C, et al. Altered executive control network resting-state connectivity in social anxiety disorder. World J Biol Psychiatry 2016;17:47-57.   DOI
62 Yuan C, Zhu H, Ren Z, Yuan M, Gao M, Zhang Y, et al. Precuneus-related regional and network functional deficits in social anxiety disorder: A resting-state functional MRI study. Compr Psychiatry 2018;82:22-29.   DOI
63 Liao W, Chen H, Feng Y, Mantini D, Gentili C, Pan Z, et al. Selective aberrant functional connectivity of resting state networks in social anxiety disorder. Neuroimage 2010;52:1549-1558.   DOI
64 Gentili C, Ricciardi E, Gobbini MI, Santarelli MF, Haxby JV, Pietrini P, et al. Beyond amygdala: default mode network activity differs between patients with social phobia and healthy controls. Brain Res Bull 2009;79:409-413.   DOI
65 Rabany L, Diefenbach GJ, Bragdon LB, Pittman BP, Zertuche L, Tolin DF, et al. Resting-state functional connectivity in generalized anxiety disorder and social anxiety disorder: Evidence for a dimensional approach. Brain Connect 2017;7:289-298.   DOI
66 Choi SH, Shin JE, Ku J, Kim JJ. Looking at the self in front of others: Neural correlates of attentional bias in social anxiety. J Psychiatr Res 2016;75:31-40.   DOI
67 Zhang W, Yang X, Lui S, Meng Y, Yao L, Xiao Y, et al. Diagnostic prediction for social anxiety disorder via multivariate pattern analysis of the regional homogeneity. Biomed Res Int 2015;2015:763965.
68 Pannekoek JN, Veer IM, van Tol MJ, van der Werff SJ, Demenescu LR, Aleman A, et al. Resting-state functional connectivity abnormalities in limbic and salience networks in social anxiety disorder without comorbidity. Eur Neuropsychopharmacol 2013;23:186-195.   DOI