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http://dx.doi.org/10.15204/jkobgy.2022.35.4.057

A Review of Randomized Controlled Trials on the Treatment Effects of Herbal Medicine for Threatened Abortion  

Rho, Eon-Ji (Dept. of Korean Obstetrics & Gynecology, College of Korean Medicine, Daegu Hanny University)
Kim, Dong-Chul (Dept. of Korean Obstetrics & Gynecology, College of Korean Medicine, Daegu Hanny University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.35, no.4, 2022 , pp. 57-76 More about this Journal
Abstract
Objectives: This review is aimed to figure out the effectiveness of herbal medicine for treating threatened abortion by analyzing randomized controlled trials. Methods: We searched relevant studies using seven databases including 4 domestic databases and 3 foreign databases. Data retrieval was conducted on May 18, 2022. and the papers published from January 1, 2018 to May 18, 2022 were included. The risk of bias was assessed by using Cochrane's risk of bias tool. Results: 182 studies were searched in domestic and foreign databases, and 9 studies were finally selected. Among 9 studies, the treatment group was treated with only oral herbal medicine in 4 studies and with combined treatment of herbal medicine and western medicine in 5 studies. On the other hand, the control group was treated with only western medicine. In all 9 studies, evaluation indexes in the treatment group showed more effectiveness than those of the control group, evaluation indexes were different for each study though. Conclusions: Herbal medicine was more effective for treating threatened abortion whether using it alone or combining with western medicine compared to using western medicine alone. Additional studies which include large number are needed to confirm long-term effectiveness and safety of herbal medicine treatment.
Keywords
Threatened Abortion; Herbal Medicine; Systemic Review;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Basama FM, Crosfill F. The outcome of pregnancies in 182 women with threatened miscarriage. Arch Gynecol Obstet. 2003;270(2):86-90.
2 National Institute for Health and Care Excellence. Ectopic pregnancy and miscarriage: diagnosis and initial management. NICE guideline. 2019:17.
3 Coomarasamy A, et al. A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy. N Engl J Med. 2019;380(19):1815-24.   DOI
4 Devall AJ, et al. Progestogens for preventing miscarriage: a network meta-analysis. Cochrane Database Syst Rev. 2021;4(4):CD013792.
5 Betts D, Smith CA, Dahlen HG. Does acupuncture have a role in the treatment of threatened miscarriage? Findings from a feasibility randomised trial and semi-structured participant interviews. BMC Pregnancy and Childbirth. 2016;16(1):1-10.   DOI
6 Hong HT, Lee TG. A case report of threatened abortion. J Korean Obstet. Gynecol. 1997;10(2):117-21.
7 Kim DI, Kang DH, Lee TK. 《景岳全書 婦人規》에 나타난 切迫流産과 관련된 理論과 治方에 대한 硏究. The Journal of Oriental Gynecology. 1999;12(1):279-96.
8 He Y. 寿胎丸治疗先兆流产临床观察. Journal of North Pharmacy. 2018;15(4):130-1.
9 Song YW, et al. Clinical effects of Yuetai decoction on blood-heat type fetal leakage and fetal irritability and its effect on blood beta human chorionic gonadotropin, progesterone, estradiol and gestational sac in patients Hebei J TCM. 2018;40(4):497-500, 579.
10 Wang YM. 补肾安胎方治疗肾虚型先兆流产的效果观察. J Med Theor & Prac. 2020;33(9):1484-6.
11 Yang Y, Zhu YP. 早期先兆流产的中西医结合治疗及症状转归分析. Electronic Journal of Clinical Medical Literature. 2019;6(56):19-20.
12 Korean Society of Obstetrics and Gynecology. Obstetrics. 6th rev. ed. Paju:Koonja Publishing Company. 2021:62-6, 539-40, 546-7.
13 Duncan WC. Did the NICE guideline for progesterone treatment of threatened miscarriage get it right? Reprod Fertil. 2022;3(2):C4-C6.   DOI
14 Peng XP. The Effectiveness of Acupuncture in The Treatment of Threatened Miscarriage Caused by Covid-19: A Case Report. J Gynecol Reprod Med. 2022;6(2):93-5.
15 Yun YJ, et al. A Case Report of Threatened Abortion. J. Korean Obstet Gynecol. 2015;28(1):167-74.   DOI
16 Cho SY, Park EJ, Yoo JE. A Case Report of Threatened Abortion And Placenta Previa Treated Twice With Korean Medical Hospitalization. J Korean Med. 2020;41(3):180-90.   DOI
17 Son JH, Kim DC. A Case Report of the Treated Threatened Abortion in a Pregnant after In Vitro Fertilization (IVF). J Korean Obstet Gynecol. 2014;27(3):143-50.   DOI
18 He YL. 寿胎丸合芍药甘草汤加减治疗先兆流产临床研究. Women's Health Research. 2019;5:50, 69.
19 Liu FH, Huang X, Lan BR. 中西医结合治疗早期先兆流产的42例临床观 察. Nei Mongol Journal of Traditional Chinese Medicine. 2018;37(12):54-5.
20 Zhang LP. 育阴汤联合黄体酮治疗先兆流产临床观察. Guangming Journal of Chinese Medicine. 2020;35(1):118-20.
21 Li YZ, Yang KL, Tan HZ. A systematic review and meta-analysis of the efficacy and safety of acupuncture in the treatment of threatened abortion. Hunan Journal of Traditional Chinese Medicine. 2018;34(7):164-9.
22 Shin JS, Kim TJ, Kim YM. Maternal Serum CA 125 Levels in Intrauterine Pregnancy and Abortion in the First Trimester. Korean J Perinatol. 2003;14(3):284-9.
23 Healthcare Bigdata Hub. Statistics of national concern/behavior. [Cited September 1,2022]. Available from: URL:http://opendata.hira.or.kr/op/opc/olapMfrnIntrsIlnsInfo.do
24 Leylek OA, Senocak F, Erselcan T. The prognostic predictive value of maternal serum CA125 levels in threatened abortion. Int J Gynecol Obstet. 1997;59(2):147-9.   DOI
25 Ocer F, et al. The prognostic significance of maternal serum CA 125 measurement in threatened abortion. Eur J Obstet Gynecol Reprod Biol. 1992;46(2-3):137-42.   DOI
26 The Society of Korean Medicine Obstetrics and Gynecology. Korean Medicine Obstetrics & Gynecology(2nd vol). 3rd rev. ed. Seoul:Euiseongdang. 2016:448-9, 454-62.
27 Liu LS, Sun L, Zhou YH. Observation on the Curative Effect of Bushen Jianpi Tocolysis in the Treatment of Kidney Deficiency Typetailouaddition and Fetal Irritability. China Continuing Medical Education. 2018;10(3):145-7.
28 Zhang HZ. The effects of the Bushen Baotai Zhuyun decoction on fetal leakage of the Shenxu type and fetal motion. Clinical Journal of Chinese Medicine. 2020;12(22):83-6.
29 The national college of Korean medicine herbology textbook compilation committee. Herbology. 3rd rev. ed. Seoul:Younglimsa. 2014:329-30, 579-81, 605-6, 618-20.