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http://dx.doi.org/10.15204/jkobgy.2021.34.3.001

A Study on the Regulation of Endometrial and Placental Cell Function by Water Extract of 3 Types of Herbal Medicines and Ethanol Extract on Scutellariae Radix  

Park, Seo-Ye (Dept. of Obstetrics and Gynecology, College of Medicine, Konyang University)
Noh, Eui-Jeong (Dept. of Obstetrics and Gynecology, College of Medicine, Konyang University)
Seo, Chang-Seob (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Lee, Sung-Ki (Dept. of Obstetrics and Gynecology, College of Medicine, Konyang University)
Shin, Hyeun-Kyoo (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.34, no.3, 2021 , pp. 1-14 More about this Journal
Abstract
Methods: We investigated the ability to induce decidualization of human endometrial stromal cells and invasive ability of human trophoblast cells by water extract of three types herbal medicines (Dangguijakyak-san, Siryung-tang, Antae-eum) and ethanol extract on Scutellariae Radix. Results: In the process of decidualization of endometrial stromal cells, three herbal medicines including Dangguijakyak-san, Siryung-tang, and Scutellariae Radix increased the production of decidual markers such as prolactin (PRL) and insulin-like growth factor-binding protein 1 (IGFBP1). However, Antae-eum increased mRNA levels of PRL and IGFBP and secretion of IGFBP in decidual stromal cells, but not PRL. Four herbal medicines inhibited the invasion of trophoblast cells. Conclusions: Four herbal medicines may play a role in implantation in women with reproductive failures. However, further studies are warranted to elucidate whether these medications are helpful in the maintenance of pregnancy.
Keywords
Endometrial Stromal Cell; Decidualization; Trophoblast; Invasion; Herbal Medicines; Dangguijakyak-san; Siryung-tang; Antae-eum; and Scutellariae Radix;
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