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http://dx.doi.org/10.15204/jkobgy.2020.33.3.149

Effect of Onkyung-tang on Cold Hypersensitivity on Feet: A Multi-center Double-blind Randomized Controlled Trial  

Kwon, Na-Yoen (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University)
Yoo, Joon-Sang (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Sang-Ji University)
Kim, Hyeong-Jun (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University)
Lee, Dong Nyung (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Se-Myung University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.33, no.3, 2020 , pp. 149-174 More about this Journal
Abstract
Objectives: This study was aimed to figure out the effect of Onkyung-tang (OKT) on cold hypersensitivity on feet in female patients. Methods: This study was designed to implement multi-center randomized clinical trial in three korean medical hospitals. The female patients who were enrolled in this study were 112 women who suffered from cold hypersensitivity on feet. They were randomly allocated into OKT group or control group in 1:1 ratio. The primary outcome was change in score of visual analogue scale of hypersensitivity on feet, and the secondary outcomes were thermometer of LU4, PC8, ST32, LR3, visual analogue scale of hypersensitivity on hands, result of cold stress test, and score of World Health Organization Quality of Life-BREF. Results: In both group, the VAS of hypersensitivity on feet and hands was decreased while taking the medicine, and the effect of decreasing the VAS continues for the 4 weeks after the end of medication (p<0.001, 0.003, 0.001). In OKT group, the body temperature difference in lower extremity (ST32-LR3) was steadily decreased at every visit and it was statistically significant(p=0.003, <0.001). On the other hand, in control group, the body temperature difference in lower extremity was decreased only while taking the medicine (p<0.001). Conclusions: OKT significantly reduced discomfort coldness on feet in patients, and the effect of treatment was maintained at least for four weeks after medication.
Keywords
Cold Hypersensitivity; Randomized Controlled Trial; OKT; Herbal Medicine;
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Times Cited By KSCI : 6  (Citation Analysis)
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