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http://dx.doi.org/10.15204/jkobgy.2019.32.4.144

A Case Study of Malignant Germ Cell Tumor Patient Experiencing Chemotherapy Side Effects Managed by Traditional Korean Medicine  

Jeong, So-Mi (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
Hwang, Deok-Sang (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
Lee, Jin-Moo (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
Lee, Chang-Hoon (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
Jang, Jun-Bock (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.32, no.4, 2019 , pp. 144-158 More about this Journal
Abstract
Objectives: The purpose of this study is to report the effect of Korean medical treatment in case of germ cell tumor patient treated by chemotherapy. Methods: The patient was treated with Korean medical treatment (herbal medicine, acupuncture) for 11 months. By taking computed tomography and laboratory testing, we could compare before and after. Results: The patient treated with combination of Korean medical treatment and Chemotherapy recovered after taking Korean medicine for 11 months. Panax ginseng, C.A. Meyer, Astragalus membranaceus, Rhus Verniciflua Stokes were main ingredient of the korean medical treatment. Conclusions: This report shows the Korean medical treatment is effective on Germ cell tumor patient. Korean medical treatment alleviates the side-effect of Chemotherapy such as nausea, vomiting, hot flush and anorexia. Also Blood test results prove long-term use of Korean medicine is safe for lung and kidney function.
Keywords
Germ Cell Tumor; Herbal Medicine; Combination Therapy; Chemotherapy; Korean Medical Treatment;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Han GJ, et al. A case study of a patient with breast cancer treated with a combination of traditional Korean medicine and chemotherapy. J Int Korean Med. 2017;38(5):820-7.   DOI
2 Kwon SJ, et al. EuiMunChuiEeon (醫門贅言) Wonju:Publishing Co. Eui bang 2014:124-6.
3 Lee JD. The Physio-pathology of Oriental Medicine with 30 Essential Herbal Formulas. Seoul:Publishing Co. Jeong-dam. 2015:414-40.
4 Song MS, et al. The Study of Literature Review on Lacas Sinicia Exsiccate. The Journal of Korean Obstetrics and Gynecology. 2002;15(1):61-76.
5 Kwon SW, et al. Korean Internal Medicine Diagnosis&Treatment (韓方內科診察診斷治療) Goyang:Guide. Gaonhamedia. 2017:84-8.
6 Ohno T, et al. Rikkunshito, a traditional Japanese medicine, suppresses cisplatin -induced anorexia in humans. Clin Exp Gastroenterol. 2011;4(1):291-6.   DOI
7 Lin JC, et al. Phase III Study of Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Advanced Nasopharyngeal Carcinoma: Positive Effect on Overall and Progression-Free Survival. J Clin Oncol. 2003;21(4):631-7.   DOI
8 Huddart RA, et al. A randomised phase 2 trial of intensive induction chemotherapy (CBOP/BEP) and standard BEP in poor-prognosis germ cell tumours (MRC TE23, CRUK 05/014, ISRCTN 53643604). Eur Urol. 2015;67(3):534-43.   DOI
9 Tryakin A, et al. Paclitaxel+BEP (T-BEP) regimen as induction chemotherapy in poor prognosis patients with non-seminomatous germ cell tumors: a phase II study. Urology. 2011;78(3):620-5.   DOI
10 Kier MG, et al. Prognostic Factors and Treatment Results After Bleomycin, Etoposide, and Cisplatin in Germ Cell Cancer: A Population-based Study. Eur Urol. 2017;71(2):290-8.   DOI
11 Chang HJ, et al. A case of Ovarian Mixed Germ cell tumor with rapid relapse. Journal of Gynecologic Oncology. 2002;13(2):171.
12 Kim CS, et al. A Literature Review of the East-West Medical Combined Treatment) Korean Institute of Oriental Medicine. 2012;18(2):101-16.
13 Dundee JW, et al. Acupuncture prophylaxis of cancer chemotherapy-induced sickness. J R Soc Med. 1989;82(5):268-71.   DOI
14 The Society of Korean Medicine Obstetrics and Gynecology. Oriental Obstetrics & Gynecology. Seoul:Publishing Co. Eui Seong Dang. 2012:347-52.
15 Ministry of Health and Welfare, National Cancer Control Institute. Cancer registration.Statistics Program. 2016.
16 Jacobs IJ, et al. Screening for ovarian cancer: a pilot randomized controlled trial. Lancet. 1999 Apr 10;353(9160):1207-10.   DOI
17 David M, et al. Managemnt of Early Ovarian Cancer: Germ cell and Sex Cord-Stromal Tumors. Gynecol Oncol. 1994;55(3):562-72.   DOI
18 Nogales FF, et al. Germ cell tumors of the ovary: an update. Arch Pathol Lab Med. 2014;138(3):351-62.   DOI
19 Nawa A, et al. Prognostic factors of patients with yolk sac tumors of the ovary. Am J Obstet Gynecol. 2001;184(6):1182-8.   DOI
20 Williams SD, et al. Adjuvant therapy of ovarian germ cell tumors with cisplaitn, etoposide, and bleomycin : a trial of the Gynecologic Oncology Group. Gynecol Oncol. 2004;95(3):496-9.   DOI
21 Zanetta G, et al. Survival and reproductive function after treatment of malignant germ cell ovarian tumors. J Clin Oncol. 2001;19(4):1015-20.   DOI
22 Lee KW, et al. A Preliminary Study for Development of Clinical Practice Guidelines of Korean Medicine in Breast Cancer. The Journal of Korean Obstetrics and Gynecology. 2016;29(2):47-66.   DOI
23 Mead GM, et al. The International Germ Cell Consensus Classification : a new prognostic factor-based staging classification for metastatic germ cell tumors. Clin Oncol. 1997;9(4):207-9.   DOI
24 Kim CM, et al. The encyclopedia of oriental herbal medicine. Publishing Co. Jungdam. 1997;(7):3473-9.
25 Wang JH, et al. 20(s)-ginsenoside Rg3 promotes apoptosis in human ovarian cancer HO-8910 cells through PI3K/Akt and XIAP pathways. Tumour Biol. 2014;35(12):11985-94.   DOI
26 Xu TM, et al. Inhibitory effect of ginsenoside Rg3 on ovarian cancer metastasis. Chin Med J (Engl). 2008;121(15):1394-7.   DOI
27 Ting Liu, et al. Ginsenoside 20(S)-Rg3 Targets HIF-$1{\alpha}$ to Block Hypoxia-Induced Epithelial-Mesenchymal Transition in Ovarian Cancer Cells. PLoS ONE. 2014;9(9):e103887.   DOI
28 Li J, et al. Ginsenoside 20(S)-Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells. Int J Oncol. 2015;46(2):775-81.   DOI
29 Zheng X, et al. Ginsenoside 20(S)-Rg3 induced autophagy to inhibit migration and invasion of ovarian cancer. Biomed Pharmacother. 2017;85:620-6.   DOI
30 National Compilation Committee of Korean Medicine college(全國韓醫科大學共同敎材編纂委員會). Herbalogy (本草學) Seoul:Publishing Co. Young rim. 2016:320-4.
31 Kang H, et al. Astragali Radix Increases Survival and Activity of Spleen Lymphocyte. Journal of physiology & pathology in Korean medicine. 2001;15(4):560-5.
32 Cho WC, et al. In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Cancer Lett. 2007;252(1):43-54.   DOI
33 Evan GI, et al. Proliferation, cell cycle and apoptosis in cancer. Nature. 2011;411(6835):342-8.   DOI
34 Park JG, et al. Effects of Astragalus membranaceus Extract on Cell Cycle and Apoptosis of Human Leiomyoma Cell. The Journal of Korean Obstetrics and Gynecology. 2008;21(2):49-58.
35 David D.Kitts, et al. Antitumorigenic and cytotoxic properties of an ethanol extract dervied from Rhus Verniciflua Stokes. J Toxical Environ Health A. 2001;64(4):357-71.   DOI
36 Oh PS, et al. Glycoprotein Isolated from Rhus verniciflua stokes Inhibits Inflammation-Related Protein and Nitric Oxide Production in LPS-Stimulated RAW 264.7 Cells. Biol Pharm Bull. 2007;30(1):111-6.   DOI
37 Nancy A. The caspase family of cysteine proteases. British Medical Bulletin. 1997;53(3):478-90.   DOI
38 Lee JH. The effect of G2 cell cycle arrest in ATM/ATR-cdc25c-cdc2-cyclin B pathway by Butein-the active material of Rhus verniciflua stokes in Human breast cancer MCF-7 cell lines. Department of Oriental Medicine, Kyung Hee Graduate School. 2010.
39 Jang HJ. Molecular mechanism by which Resina Toxicodendrii induces apoptosis and suppresses chemo-resistance in MCF-7/DOX cells. Department of Clinical Korean Medicine, Kyung Hee Graduate School. 2017.
40 Williams P, et al. Apoptosis: Pharmacological Implications and Therapeutic Opportunities. Mayo Clinic Proceedings. 1998;73(9):917.
41 Shin MG. Clinical Traditional Herbalogy. Seoul:Publishing Co. Young-rim. 1989:55-7
42 Lee DH, et al. A case report of metastatic breast cancer treated with korean medicine therapy as a substitute for chemotherapy. Case Rep Oncol. 2017;10(1):27-36.   DOI
43 Han GJ, et al. A case study of an advanced breast cancer patient treated with a combination of traditional korean medicine and chemotherapy. J Int Korean Med. 2018;39(2):268-76.   DOI