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http://dx.doi.org/10.15204/jkobgy.2018.31.4.089

Clinical Research of the Effect of Traditional Herbal Medicine with In Vitro Fertilization and Embryo Transfer in Pubmed  

Lee, Mi-Joo (Dept. of Korean Gynecology, CHA Bundang Medical Center, CHA University)
Son, Sung-Se (Dept. of Acupuncture & Moxibustion, CHA Bundang Medical Center, CHA University)
Park, Seung-Hyeok (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
Park, Kyoung-Sun (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
Hwang, Deok-Sang (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
Lee, Jin-Moo (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
Jang, Jun-Bock (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
Lee, Chang-Hoon (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.31, no.4, 2018 , pp. 89-109 More about this Journal
Abstract
Objectives: The purpose of this systematic review is to assess the effects of herbal medicine with in vitro fertilization-embryo transfer (IVF-ET) based on the current evidence. Methods: Eligible randomized controlled trials (RCT) searched from Pubmed which compared a combination of herbal medicine and IVF with IVF alone were included. Results: Sixteen trials, in which 2025 women involved, were included in this review. The review results showed that the effect of traditional herbal medicine can improve the clinical pregnancy rate (herbal medicine intervention: 30.36~63.64%, Control: 9.38~47.5%) and rate of high quality oocytes and embryos. The mechanism may be through regulating follicular fluid to improve microenvironment for oocytes which would lead to a successful embryo implantation. Conclusions: This analysis showed that combination of IVF and traditional herbal medicine used in the included trials improve clinical pregnancy rate and IVF success. During in vitro fertilization, TCM can regulate the microenvironment in the follicular fluid to mature the oocyte, improve the quality of the embryo, and help the development and implantation of the embryo. Further large randomized placebo controlled trials are needed to confirm the effectiveness of traditional herbal medicine with concurrent IVF.
Keywords
In Vitro Fertilization; Embryo Transfer; Herbal Medicine; Pregnancy Rate;
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1 Hwang NM, et al. Assessment of infertile couples support project and analysis 2015[online]. Available from: URL:http://www.prism.go.kr/homepage/entire/retrieveEntireDetail.do?research_id=1351000-201600303.
2 Cho JH, Lee KS, Song BK. Study on the effects of Samul-Tang for IVF in mice. J Korean Obstet Gynecol. 2000; 13(1):94-110.
3 Sung YS. Effects of Yuklinju on in vitro fertilization and embryo transfer. J Korean Obstet Gynecol. 1999;12(1):161-84.
4 Lee SJ, et al. Effect of Jokyong-Jongok -tang on the fertilization and maturation of immmature oocytes in bovine. J Korean Obstet Gynecol. 1999;12(2):134-47.
5 Koh YM. A study on the effect of Yukmijihwangtang for IVF. J Korean Obstet Gynecol. 2001;14(1):146-56.
6 Moon HJ, G MJ. Clinical Efficacy of Oriental Medicine in In Vitro Fertilization (IVF). J Korean Obstet Gynecol. 2001; 14(3):127-35.
7 Bae GM, et al. Investigation of Clinical Research of Acupuncture Intervention in Assisted Reproductive Technology in Pubmed. J Korean Obstet Gynecol. 2009;22(4):65-82.
8 Kim DI. Oriental Medical Treatment as Supplementary Treatment Method in ART clinical review. J Korean Obstet Gynecol. 2010;23(4):67-79.   DOI
9 Xu XJ, et al. Effect of traditional Chinese comprehensive therapy on gestation in patients with previously failed in vitro fertilization and embryo transfer. J Tradit Chin Med. 2015; 35(4):428-33.   DOI
10 Guo J, et al. Intervention of controlled ovarian hyperstimulation cycle by Chinese medical herbs for Shen tonifying, blood nourishing and activating: a randomized clinical trial. Chinese Journal of Integrated Traditional and Western Medicine. 2013;33(4):484-7.
11 Lian F, et al. Effects of Chinese Medicines for Tonifying the Kidney on DNMT1 Protein Expression in Endometrium of Infertile Women During Implantation Period. J Altern Complement Med. 2013;19(4):353-9.   DOI
12 Guo J, et al. Effects of Chinese herbs combined with in vitro fertilization and embryo transplantation on infertility: a clinical randomized controlled trial. J Tradit Chin Med. 2014;34(3):267-73.   DOI
13 Lian F, et al. Clinical study on effect of Erzhi Tiangui Granule in improving the quality of oocytes and leukemia inhibitory factor in follicular fluid of women undergoing in vitro fertilization and embryo transfer. Chinese Journal of Integrated Traditional and Western Medicine. 2007;27(11):976-9.   DOI
14 Lian F, Zhao B, Lu XM. Effect of erzhi tiangui granule on metabonomics and level of Ca2+ in follicle fluid in patients after in vitro fertilization and embryo transfer. Chinese Journal of Integrated Traditional and Western Medicine. 2010;30(1):22-5.
15 Lian F, et al. Effects of Liuwei Dihuang Granule on the Outcomes of In Vitro Fertilization Pre-Embryo Transfer in Infertility Women with Kidney-Yin Defi ciency Syndrome and the Proteome Expressions in the Follicular Fluid. Chinese Journal of Integrative Medicine. 2014;20(7):503-9.   DOI
16 Yu S, Kuang YP, Qi cong. Effects of Yupei Qisun Sequential Method of Chinese medicine on correlated indices of repeated implantation failure patients in the fresh cycle. Journal of integrated traditional and western medicine. Chinese Journal of Integrated Traditional and Western Medicine. 2012;32(6):763-5.
17 Lian F, Jiang XY. Effect of Kuntai Capsule on the Number of Retrieved Oocytes, High-quality Oocytes and Embryos in in vitro Fertilization of Poor Ovarian Response Patients. Chinese Journal of Integrated Traditional and Western Medicine. 2014;34(8):917-21.
18 Liang, et al. Effect of bushen tiaojing recipe on the quality of the oocytes and reproductive hormones in the follicular fluid in IVF-ET patients. Chinese Journal of Integrated Traditional and Western Medicine. 2014;34(8):911-6.
19 Zhang Z, Zhang XH, He TY. Smoothing Gan Reinforcing Shen Method Adjuvantly Treated Poor Response of Diminished Ovari- an Reserve Patients in in vitro Fertilization and Embryo Transfer: a Clinical Study. Chinese Journal of Integrated Traditional and Western Medicine. 2015;35(10):1170-4.
20 Gao X, et al. Effect of soothing liver therapy on oocyte quality and growth differentiation factor-9 in patients undergoing in vitro fertilization and embryo transfer. J Tradit Chin Med. 2013;33(5):597-602.   DOI
21 Chang XF, Du HL, Gao X. Effect of bushen tiaojing recipe on growth differentiation factor-9 in tubal infertility patients undergoing in vitro fertilization-embryo transfer. Chinese Journal of integrated traditional and western medicine. 2011;31(6):780-3.
22 Dyer S, et al. International committee for monitoring assisted reproductive technology report:Assited reproductive technology 2008, 2009 and 2010. Hum Reprod. 2016;31(7):1588-609.   DOI
23 Ge MX, Zhang JY, Zhao YP. Effect of Chinese drugs for supplementing qi-blood and nourishing gan-shen on transforming growth factor beta1, and sex hormone levels in the follicle fluid of women during IVF-ET. Chinese Journal of integrated traditional and western medicine. 2011;31(3):327-30.   DOI
24 Wu JZ, Liu Y, Huang CY. Effect of Chinese herbal medicine in the natural cycle of frozen embryo transfer. Chinese Journal of integrated traditional and western medicine. 2008;28(7):591-3.   DOI
25 Zhang XL. Clinical Observations of Sequential Therapy with Chinese Medicine and Hysteroscopic Mechanical Stimulation of the Endometrium in Infertile Patients with Repeated Implantation Failure Undergoing Frozen-Thawed Embryo Transfer. Chin J Integr Med. 2015;21(4):249-53.   DOI
26 Lee TH. Physiology of Pregnancy and Epidemiology of Infertility. J Korean Med Assoc 2007;50(5):395.
27 Assisted reproductive technology(ART) committee. Current Status of Assisted Reproductive Technology in Korea, 2007. Korean Journal of Obstetrics and Gynecology. 2010;53(12):1052-77.   DOI
28 Jin ST. Elaborate Seoksilbirok. 1st ed. Taipei:Taeyeongukpung. 1974:121-2.
29 Huh J. Dong-ui-bo-gam. 1st ed. Seoul:Bubin. 2005:1090-3.
30 Cao HJ, et al. Can chinese herbal medicine improve outcomes of in vitro ferfilization? A systematic review and meta-analysis of randomized controlled trials. PLOS ONE. 2013;8(12):e81650(1-12).   DOI
31 Moon SY. In vitro fertilization program. J Korean Med Assoc. 2007;50(5):431-9.   DOI
32 Baker VL, et al. Gonadotropin dose is negatively correlated with live birth rate: analysis of more than 650,000 assisted reproductive technology cycles. Fertil Steril. 2015;104(5):1145-52.e1-5.   DOI
33 Wikipedia. Leukemia inhibitory factor [online]. [cited Sep 9, 2018]. Available from:URLhttps://en.wikipedia.org/wiki/Leukemia_inhibitory_factor.
34 Bae SJ, et al. Investigation of the 61 Cases with Korean Medical Therapy (KMT) after in Vitro Fertilization (IVF). J Korean Obstet Gynecol. 2015;28(4):1-10.   DOI
35 Lee JY. Population Trend Survey(Statistics of birth and death)[online]. [cited 2018 Feb 28]. Available from:http://kostat.go.kr/portal/korea/kor_nw/2/1/index.board?bmode=read&aSeq=366414.
36 Hwang NM. Status and results of government funding of infertility[online]. [cited 2016 May 2]. Available from: URL:https://www.kihasa.re.kr/web/publication/periodical/issue_view.do?pageIndex=5&keyField=&searchStat=&menuId=50&key=&tid=38&bid=21&searchForm=&aid=415&ano=1.