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http://dx.doi.org/10.15204/jkobgy.2018.31.2.049

Effects of Hwanggimacmundong-tang on Body Weight and Gene Expression in Obese Rats with Estrogen Deficiency  

Lee, Hye-In (Dept. of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Dae-Jeon University)
Yoo, Dong-Youl (Dept. of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Dae-Jeon University)
Yoo, Jeong-Eun (Dept. of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Dae-Jeon University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.31, no.2, 2018 , pp. 49-67 More about this Journal
Abstract
Objectives: This study was conducted to assess the effects of Hwanggimacmundong-tang extract (HM) on obese rats with estrogen deficiency. Methods: The experiments were performed with ovariectomized rats as estrogen-deficient obesity model. Rats were grouped NC (Normal Control Group; sham operation group), OC (Obesity Control Group; estrogen-deficient group), HML (20 mg/kg/day), HMH (100 mg/kg/day). HM was administered orally for six weeks. Body weights and serum lipid level were measured, and real-time PCR was performed to estimate the effect of HM on gene expression in liver. Results: HM decreased the total cholesterol and triglyceride in serum. And HM increased leptin, CPT1 gene expression in liver tissue of obese rats with estrogen deficiency. However HM decreased $PPAR{\gamma}$, $PGC-1{\alpha}$, HMGCR, CYP8B1, LPL, ACAT1, ACAT2, ApoB, ACOX gene expression in liver tissue of obese rats with estrogen deficiency. Conclusions: It is concluded that HM reduced total cholesterol and triglyceride in serum, and regulate gene expression related to lipid metabolism. These results indicate Hwanggimacmundong-tang that might have potential for treatment of obesity and complications during the menopause caused by estrogen-deficiency.
Keywords
Hwanggimacmundong-tang; Obesity; Menopause; Estrogen-deficiency; Gene Expression;
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Times Cited By KSCI : 6  (Citation Analysis)
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