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http://dx.doi.org/10.15204/jkobgy.2018.31.1.043

Screening Herbal Decoction of the Vascular Relaxation in Korean Medicine  

Kim, Hye-Yoom (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University)
Seo, Chang-Seob (K-herb Research Center, Korea Institute of Oriental Medicine)
Shin, Hyeun-Kyoo (K-herb Research Center, Korea Institute of Oriental Medicine)
Hong, Mi-Hyeon (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University)
Yoon, Jung-Joo (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University)
Ahn, You-Mee (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University)
Eun, So-Young (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University)
Lee, Yun-Jung (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University)
Lee, Ho-Sub (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University)
Kang, Dae-Gill (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.31, no.1, 2018 , pp. 43-56 More about this Journal
Abstract
Objectives: This study was designed to investigate the basis for developing the herbal decoction that may help promote healthy blood vessels in accordance with the basic principles of Korean medicinal materials. Methods: In this study, we investigated the vascular relaxation effects of fifty herbal decoctions on vascular response in isolated thoracic aorta of phenylephrine-preconracted rats. Results: The results of identify the vascular relaxation effect of fifty herbal decoctions provided by Korea Institute of Korean Medicine, twenty-one herbal decoctions showed vascular relaxation effects. Among them, four herbal decoctions, Mahwang-tang (麻黃湯), Samchulgeonbi-tang (參朮健脾湯), Cheonwangbosim-dan (天王補心丹), and Socheonglyong-tang (小靑龍湯), with showed significantly concentration-dependent vasodilation was examined. Vascular relaxation level are $84.02{\pm}4.70$, $79.39{\pm}13.9$, $51.26{\pm}12.56$, and $54.73{\pm}15.8%$, respectively (P<0.05, 0.01, and 0.001). Conclusions: Thus these results provide a basic data for the treatment of the impairment of vascular function and blood pressure in traditional Oriental medicine.
Keywords
Herbal Decoction; Vascular Relaxation; Vasodilation; Blood Vessel; Thoracic Aorta;
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