Browse > Article
http://dx.doi.org/10.15204/jkobgy.2016.29.2.015

Effect of Samki-eum Gamibang Water Extract on Dexamethasone-treated Osteoblast  

Lee, Hye-In (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University)
Jang, Sae-Byul (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University)
Yoo, Jeong-Eun (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University)
Yoo, Dong-Youl (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.29, no.2, 2016 , pp. 15-28 More about this Journal
Abstract
Objectives : The purpose of this study is to evaluate the effect of water extract of Samki-eum Gamibang (SKG) on osteoblast proliferation in murine calvarial cells. Methods : The osteoblast separated from calvariae of murine was cultivated and evaluated the function of cell. After the addition of SKG on the culture medium, we investigated the effect of SKG on the cell viability, cell proliferation, alkaline phosphatase (ALP) activity, bone matrix protein synthesis and collagen synthesis of the cultivated osteoblast.Results : SKG increased the survival rate and proliferation of rat calvarial osteoblast. SKG increased ALP activity, bone matrix protein synthesis and collagen synthesis of rat calvarial osteoblast. Conclusions : This study suggests that SKG has effect on glucocorticoid-induced osteoporosis (GIO) resulting from increase of osteoblast function.
Keywords
Samki-eum Gamibang (SKG); glucocorticoid-induced osteoporosis (GIO); osteoporosis; osteoblast;
Citations & Related Records
Times Cited By KSCI : 11  (Citation Analysis)
연도 인용수 순위
1 Kanis JA. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int. 1994;4(6):368-81.   DOI
2 Korean Society for Bone and Mineral Research. Textbook of Osteoporosis. 4rd ed. Seoul:KoonJa publisher. 2013: 5, 217-29.
3 Kim SY, Kim HJ. Glucocorticoid-induced Osteoporosis; Update. J Korean Orthop Assoc. 2009;44(2):151-8.   DOI
4 Buckley LM, et al. Variation in physician’s judgements about corticosteroid-induced osteoporosisby physician speciality. Journal of Rheumatology, 1998;25(11):2195-202.
5 Kang SK, Park YB, Ahn HS. The bibliographical studies on the acupuncture treatment of the osteoporosis. The J of Korean Acupuncture & Moxibustion Society. 1995;11(2):171-90.
6 Korean academy of oriental rehabilitation medicine. Oriental rehabilitation medicine. Seoul:KoonJa publisher. 2003;4:105-6.
7 Jang GB. Kyungakjeonsuh Formulary. Seoul:Bubin publisher. 2007:96.
8 Hwang DY. Jeungmaek Bangyakapyeon. Seoul:Namsandang publisher. 2009:136.
9 Jeon GT. Experimental Studies on the Effects of Binsosan and Sangieum on Adjuvant Arthritis. Graduate School of Daejeon University. 1994.
10 Lee KM, et al. Effects of Samgi-eum (Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats. Journal of Korean Medicine Rehabilitation. 2008;18(2):17-31.
11 Choi ES. Effects of Samki-eum (sanqi-yin) on Freund’s Complete Adjuvant-induced Arthritic Rats. Journal of Korean Medicine Rehabilitation. 2013;23(3):1-14.
12 Kim SJ, Lee CW. The Experimental Study of Samgium and Samgium (except Kyungpobuja) on the Affecting of Free Radical Generating System by Adjuvant Arthritis-Induced Rats. Journal of Korean Medicine Rehabilitation. 1997;7(2):1-45.
13 Lee HC. The preventive and healing effects of Gamikobonkeonyangtang and Gagamsamkiyum on Osteoporos is in Ovariectomized Rats. Graduate School of Kyung Hee University. 2000.
14 Kim YG, Kim KH. Studies on the Analgesic, Anti-inflammatory effect of Samgi-um and Samgi-um with Buthus. Kyung Hee University. 1983;6(1):257-63.
15 Lee DY. Effects of Samkieum(SK) on Osteoblast Function. Graduate School of Kyungwon University. 2004.
16 Park SM, Yoo DY. Effects of Samkieumgamibang Extract on Osteoclast Differentiation and Osteoblast Function. J Korean Obstet & Gynecol. 2012;25(2):23-42.
17 Yu SJ, et al. A Comparative Study of BMD between Osteoporosis Patients Taking Fosamax and Taking Fosamax and Samgieumgamibang. J Korean Obstet & Gynecol. 2012;25(1):11-9.
18 Lim SM, et al. The Study on the Effects of Samgiyeum(SGY) and Tongbiyeum(TBY) on Thrombosis and Brain Damage. Korean J Orient int Med. 2002;23(4):617-26.
19 Smith E, Coetzee GA, Frenkel B. Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta. J Biol Chem. 2002;277:18191-7.   DOI
20 Lim SG. Recent trends of Osteoporosis research. Biochemistry and molecular biology news. 2002;22(3):270-6.
21 Lim YW, Kim YS, Sun DH. Osteoporosis: Pathogenesis and Fracture Prevention. Hip & pelvis. 2009;21(1):6-16.
22 Min YG. The Effects of Glucocorticoids on Osteoblast. Endocrinology and Metabolism. 2002;17(1):20-2.
23 Canalis E. Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab. 1996;81(10):3441-7.   DOI
24 Pereira RC, Delany AM, Canalis E. Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. Bone. 2002;30(5):685-91.   DOI
25 Weinstein RS, Nicholas RW, Manolagas SC. Apoptosis of osteocytes in glucocorticoid -induced osteonecrosis of the hip, J Clin Endocrinol Metab. 2000;85(8) :2907-12.   DOI
26 Pereira RM, Delany AM, Canalis E. Cortisol inhibits the differentiation and apoptosis of osteoblasts in culture. Bone. 2001;28:484-90.   DOI
27 Ohnaka K, et al. Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts. Biochem Biophys Res Commun. 2005;329:177-81.   DOI
28 Weinstein RS. Glucocorticoid-induced osteoporosis. Rev Endocr Metab Disord. 2001;2:65-73.   DOI
29 Mankin HJ. Nontraumatic necrosis of bone (osteonecrosis). N Engl J Med. 1992;326(22):1473-9.   DOI
30 Adachi JD, Bensen WG, Brown J. Intermittent etidronate therapy to prevent glucocorticoid-induced osteoporosis. N Engl J Med. 1997;337:382-7.   DOI
31 Aloia JF, Vaswani A, Neunier PJ. Coherence treatment of postmenopausal osteoporosis with growth hormone and calcitonin. Calcif Tissue Int. 1987; 40:253-9.   DOI
32 Aloia JF, Vaswani A, Kapoor A. Treatment of osteoporosis with calcitonin with and without growth hormone. Metabolism. 1985;34:124-8.   DOI
33 Eastell R, Reid DM, Compstone J. A UK consensus group on management of glucocorticoid-induced osteoporosis: an update. J Intern Med. 1998;244:271-92.   DOI
34 Reginster JY, Henrotin Y, Gosset C. Promising new agents in osteoporosis. Drugs RD. 1999;1:195-201.   DOI
35 Buckley LM, et al. Variation in physician’s judgements about corticosteroid-induced osteoporosis by physician speciality. J Rheumatol. 1998;25:2195-202.
36 Kim JH, Lee H. A Study of Herbal-acupuncture with Cyperi Rhizoma Infusion Solution on Osteoporotic Rats Induced by Ovariectomy. The J of Korean Acupuncture & Moxibustion Society. 2008;25(2):243-57.
37 Buckley LM, et al. Prevention of corticosteroid-induced osteoporosis : results of a patient survey. Arthritis Rheum. 1999;42:1736-9.   DOI
38 Osiri M, et al. Practice pattern variation among internal medicine specialists in the prevention of glucocorticoid-induced osteoporosis. Journal of Clinical Rheumatology. 2000;6:117-22.   DOI
39 Bae BC. Geumseok Whangjenaegyeong somun. Seoul:Sungbo publisher. 1994: 131, 134, 255, 320.
40 National Oriental Medicine School Coeditorship of Herbal Medicines Professors. Herbal Medicine. 2nd rev. ed. Seoul:Youngrimsa. 2008:161, 168, 345, 372, 377, 466, 583, 602, 629, 632, 634, 654.
41 Jeong HR, et al. Antioxidant and Neuronal Cell Protective Effects of an Extract of Houttuynia cordata Thunb (a Culinary Herb). Korean J Food Preserv. 2010;17(5):720-6.
42 Yang SA, et al. Effects of Aralia continentalis Kitagawa on Antiplatelet and Antioxidative Activities. Journal of Life Science. 2008;18(3):357-62.   DOI
43 Yang GY, Kim YI, Lee H, et al. A study on the effect of herbal-acupuncture with angelicae pubescentis radix solution at joksamni on collagen-induced arthritis. The J of Korean Acupuncture & Moxibustion Society. 2006;23(3):191-206.
44 Kim JH, Kim YS, Lim EM. Immune Enhancing Effect of Houttuyniae Herba on Mouse Macrophage. J Korean Obstet & Gynecol. 2012;25(2):12-22.
45 Hwang IS, et al. Anti-inflammatory Effect of Houttuyniae Herba Water Extract on LPS-induced RAW 264.7 Mouse Macrophages. Kor J Herbology. 2014;29(4):83-9.
46 Shin CS, Cho HY. Bone Remodeling and Mineralization, Endocrinology and Metabolism, 2005;20(6):543-55.
47 Stein GS, Lian JB, Owen TA. Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation. FASEB J. 1999;4(13):3111-23.