Browse > Article
http://dx.doi.org/10.15204/jkobgy.2013.26.3.073

A Study on Factors Influencing Pregnancy in the Pilot Project for Korean Medical Treatment for Subfertility  

Ahn, In-Suk (Dept. of Obstetric & Genecology, College of Korean Medicine, Dong-Guk University)
Kim, Dong-Il (Dept. of Obstetric & Genecology, College of Korean Medicine, Dong-Guk University)
Choi, Min-Sun (Dept. of Obstetric & Genecology, College of Korean Medicine, Dong-Guk University)
Jang, Suk-Woo (Dept. of Obstetric & Genecology, College of Korean Medicine, Dong-Guk University)
Jeong, Jae-Cheol (Dept. of Obstetric & Genecology, College of Korean Medicine, Dong-Guk University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.26, no.3, 2013 , pp. 73-84 More about this Journal
Abstract
Objectives: This study aims to identify associated factors in female infertility treatment using herbal medicine, acupuncture and moxibustion. Methods: Acupuncture and moxibustion treatments were performed with intake of herbal medicines (Jokyungjongoktanggagam-bang, Sutaehwangagam-bang) for six menstrual cycles in 32 subfertile women. The variables selected for initial analysis were age, duration and type of infertility, frequency of previous In Vitro Fertilization (IVF) and live births, weekly frequency of sexual intercourse, number of treatment cycles, endometrial thickness on MCD15 and hormonal parameter (anti-mullerian hormone, follicle-stimulating hormone, luteinizing hormone, estrone). Results: Six patients became pregnant (18.75%) and seven patients withdrew. Factors influenced pregnancy were age (${\leq}35$ years), a shorter duration of infertility (<6 years), frequency of IVF (${\leq}3$), anti-mullerian hormone level (>1 ng/ml), and number of treatment cycles(${\leq}3$ cycles). Conclusions: Korean medicine is a useful and optimized treatment option for women with younger age, fewer previous IVF cycles, shorter infertile duration and normal anti-mullerian hormone level at first 3 cycles of treatment.
Keywords
Infertility; Subfertility; Prognostic factors; Herbal medicine; Acupuncture;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 대한한방부인과학회. 한방여성의학(하). 서울:의성당. 2012:203-17.
2 허준. 동의보감. 하동:동의보감출판사. 2005:1745.
3 김준태 등. 불임에 응용된 침구치료혈에 관한 문헌적 고찰. 대한침구학회지. 1997;14(2):93-113.
4 Ried K, Stuart K. Efficacy of Traditional Chinese Herbal Medicine in the management of female infertility: a systematic review. Complement Ther Med. 2011;19(6):319-31.   DOI   ScienceOn
5 황나미 등. 저출산 극복을 위한 불임부부 지원사업 현황과 정책방향. 한국보건사회연구원. 2010.
6 유심근 등. 여성 불임 원인에 대한 문헌적 고찰. 대한한의학회지. 2000;6(1): 60-7.
7 윤정석 등. 여성불임의 침치료와 구치료에 대한 문헌적 비교연구. 대한한방부인과학회지. 2000;13(1):532-56.
8 조진형. IVF 시술 실패한 여성 불임환자 1례와 남성 불임환자 1례의 임상보고. 대한한방부인과학회지. 2012; 25(4):94-104.
9 정아롱 등. 원인불명으로 진단받은 속발성 불임환자 1례의 임상보고. 대한한방부인과학회지. 2007;20(4):234-43.
10 위효선 등. 꽃마을한방병원 한방부인과에 불임을 주소로 내원한 환자에 대한 실태분석. 대한한방부인과학회지. 2005;18(1):218-33.
11 장희재 등. 한방병원에 내원한 여성불임 환자의 실태 변화 연구. 대한한방부인과학회지. 2010;23(3):184-91.
12 권수경 등. 최근 3년간 일개 불임전문 한방병원에 내원한 불임환자의 실태분석과 한방불임치료정책에 대한 제언. 대한한의학회지. 2006;27(2):44-56.
13 황도연. 신증방약합편. 서울:영림사. 2002:173.
14 박영선, 백정한. 체외수정 시술 전 한방치료가 여성 불임 환자의 임신성공율에 미치는 영향. 대한한의학회지. 2011; 32(5):25-40.
15 장석순. 醫學衷中參西錄. 서울:의성당. 1999:640-3.
16 Steptoe PC, Edwards RG. Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet. 1976;1(7965): 880-2.
17 Nygren KG, et al. International Committee for Monitoring Assisted Reproductive Technology(ICMART) world report: assisted reproductive technology 2003. Fertil Steril. 2011; 95(7):2209-22.   DOI   ScienceOn
18 Ng EH, et al. The role of acupuncture in the management of subfertility. Fertil Steril. 2008;90(1):1-13.   DOI   ScienceOn
19 Huang JY, Rosenwaks Z. In vitro fertilisation treatment and factors affecting success. Best Pract Res Clin Obstet Gynaecol. 2012;26(6):777-88.   DOI
20 Pouly JL, et al. Factors affecting the cumulative live birth rate in IVF cycles. Retrospective analysis of a 1001 couples cohort. Gynecol Obstet Fertil. 2012; 40(4):219-25.   DOI   ScienceOn
21 Merviel P, et al. Predictive factors for pregnancy after intrauterine insemination(IUI): an analysis of 1038 cycles and a review of the literature. Fertil Steril. 2010;93(1):79-88.   DOI   ScienceOn
22 Kang BM, Wu TC. Effect of age on intrauterine insemination with frozen donor sperm. Obstet Gynecol. 1996; 88(1):93-8.   DOI   ScienceOn
23 이도근 등. 여성의 연령이 체외수정시술의 예후에 미치는 영향에 관한 연구. 대한산부인과학회지. 1996;39(8) :1489-96.
24 Dodson WC, Haney AF. Controlleded ovarian hyperstimulation and intrauterine insemination for treatemnt of infertility. Fertil Steril. 1991;55(3):457-67.   DOI
25 National Collaborating Centre for Women's and Children's Health (UK). Fertility: Assessment and Treatment for People with Fertility Problems. London:RCOG Press. 2004:101-20.
26 Abdalla HI, et al. Age, pregnancy and miscarriage: uterine versus ovarian factors. Hum Reprod. 1993;8:1512-7.   DOI
27 양윤석 등. CC/hMG 배란유도 인공수정시 치료 결과에 영향을 주는 요인. 대한산부인과학회지. 2004;47(7): 1376-84.
28 Zadehmodarres S, et al. Intrauterine insemination with husband semen: an evaluation of pregnancy rate and factors affecting outcome. J Assist Reprod Genet. 2009;26(1):7-11.   DOI
29 Nuojua-Huttunen S, et al. Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. Hum Reprod. 1999;14(3):698-703.   DOI   ScienceOn
30 Templeton A, et al. Factors that affect outcome of in-vitro fertilization treatment. Lancet. 1996;348(9039):1402-6.   DOI   ScienceOn
31 강은희 등. 과배란유도주기에서의 자궁강내 인공수정시 초음파로 관찰된 자궁내막의 특성과 임신율과의 상관 관계. 대한산부인과학회지. 1996;39(2): 365-73.
32 La Marca A, et al. Anti-Mullerian hormone(AMH) as a predictive marker in assisted reproductive technology (ART). Hum Reprod Update. 2010; 16(2):113-30.   DOI   ScienceOn
33 Jayaprakasan K, et al. A prospective, comparative analysis of anti-Müllerian hormone, inhibin-B, and threedimensional ultrasound determinants of ovarian reserve in the prediction of poor response to controlled ovarian stimulation. Fertil Steril. 2010;93(3): 855-64.   DOI   ScienceOn
34 Siverberg KM, et al. A prospective randomized trial comparing two different intrauterine insemination regimens in controlled hyperstimulation cycles. Fertil Steril. 1992;57(2):357-61.   DOI
35 Nelson SM, et al. Anti-Müllerian hormone-based approach to controlled ovarian stimulation for assisted conception. Hum Reprod. 2009;24(4): 867-75.
36 Broer SL, et al. The role of anti- Müllerian hormone assessment in assisted reproductive technology outcome. Curr Opin Obstet Gynecol. 2010;22(3): 193-201.   DOI
37 대한한의사협회 저출산, 고령화 특별대책위원회. 난임한방임상진료지침. 서울:대한한의사협회. 2010:6-7.