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http://dx.doi.org/10.15204/jkobgy.2013.26.3.001

The Effect of Samul-tanggahyangbuja on Depression and Learning on Repeated Stress in Ovariectomized Rats  

Lee, Soon-Yee (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Won-Kwang University)
Kim, Song-Baek (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Won-Kwang University)
Seo, Yun-Jung (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Won-Kwang University)
Choi, Chang-Min (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Won-Kwang University)
Cho, Han-Baek (Dept. of Korean Gynecology and Obstetrics, College of Korean Medicine, Won-Kwang University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.26, no.3, 2013 , pp. 1-17 More about this Journal
Abstract
Objectives: In this research, the effect of samul-tanggahyangbuja on depression and learning in ovariectomized rats subjected to repetitive stress were assessed. Samul-tanggahyangbuja is the prescription consisting of Samul-tang and Cyperi Rhizoma. Methods: Ovariectomized rats were repeatedly stressed over a 2-week period. After being orally medicated with samul-tanggahyangbuja (100 or 400 mg/kg), rats performed the Morris water maze test and forced swimming test, and social exploration was assessed in a behavior test. As well, sucrose intake was measured and measurements of blood serum corticosterone and the change of interleukin-$1{\beta}$ (IL-$1{\beta}$) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) in blood samples were made. Results: 1. In the Morris water maze test, rats medicated with 100 mg samul-tanggahyangbuja mastered the maze in a shorter time on the 4th day in comparison with the control group, while rats medicated with 400 mg samul-tanggahyangbuja mastered the maze more quickly (p<0.05 on the 3rd day ; p<0.01 on the 4th day, as compared to control). 2. Immobility time in the forced swimming test was significantly decreased in rats receiving 400 mg samul-tanggahyangbuja compared with the control group (p<0.05). 3. Sucrose intake and active social behavior of rats receiving 400 mg samul-tanggahyangbuja were markedly increased in comparison with the control group (p<0.01). 4. Blood serum corticosterone measurements revealed decreased blood serum corticosterone level after medicating with samul-tanggahyangbuja. But it was not statistically significant. 5. Treatment with either dose of samul-tanggahyangbuja significantly reduced IL-$1{\beta}$ and TNF-${\alpha}$ (p<0.05). Conclusions: These results suggest that samul-tanggahyangbuja possesses the anti-depressant and cognitive-enhancing activities related to menopause.
Keywords
Menopausal depression; Samul-tanggahyangbuja; Morris Water Maze Test; Forced Swimming Test; Corticosterone; Cytokine;
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Times Cited By KSCI : 1  (Citation Analysis)
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