Browse > Article
http://dx.doi.org/10.15204/jkobgy.2012.25.3.071

Effects of Pueraria lobata on Body Weight and Gene Expression in Obese Rats Muscle with Estrogen Deficiency  

Shin, Hee-Jong (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University)
Yoo, Jeong-Eun (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University)
Jung, Eun-Hye (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University)
Yoo, Dong-Youl (Dept. of Oriental Gynecology, College of Oriental Medicine, Dae-Jeon University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.25, no.3, 2012 , pp. 71-84 More about this Journal
Abstract
Objectives: GG is the EtOH fraction of extract of Pueraria lobata. In this study, we aimed to elucidate a possibility that GG reduce obesity and obesity-derived complications such as cardiovascular and metabolic disease. Methods: The effects of GG on the estrogen-deficient obese rats and the level of gene expression in muscle of rats were investigated. Results: GG decreased body weight in obese rats with estrogen deficiency. GG increased leptin gene expression in obese rats with estrogen deficiency. GG decreased TNFa gene expression in obese rats with estrogen deficiency. And GG increased PPAR-gamma, PGC-1a, Prdx6, FDFT1, and ACC gene expression of those in obese rats. Conclusions: We conclude GG might reduce body weight and regulate gene expression of muscle in obese rats.
Keywords
Pueraria lobata; Gene expression of muscle; Obesity;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 대한비만학회. 임상비만학. 서울:고려의학. 2008:1, 12, 143.
2 한의부인과학 편찬위원회. 한의부인과학 上. 서울:도서출판 정담. 2001:383-4.
3 Eckel RH. Obesity-mechanism and clinical management. USA:Lippincott Williams & Wilkins. 2003:3-102.
4 Cooke PS, Naaz A. Role of Estrogens in Adipocyte Development and Function. Experimental biology and medicine. 2004;229(11):1127-35.   DOI
5 대한산부인과학회 교과서 편찬위원회. 부인과학 제4판. 서울:고려의학. 2007: 594-5.
6 한방약리학 교재편찬위원회. 한방약리학 제3판. 서울:신일북스. 2010:410-5.
7 부일권, 김연섭. 갈근이 뇌허혈 손상 흰쥐의 해마신경세포 손상에 미치는 영향. 대한본초학회지. 2004;19(1):77-82.
8 장승욱, 김연섭. 갈근(葛根)이 좌골신경 손상 흰쥐의 후지 근육위축에 미치는 영향. 동의생리병리학회지. 2009; 23(2):405-11.
9 홍재의 등. 갈근(葛根) 추출물이 cisplatin 에 의해 유도된 rat mesangial cell의 apoptosis에 미치는 영향. 동의생리병리학회지. 2010;24(2):220-7.
10 김홍배 등. 갈근추출액이 알레르기 염증반응에 미치는 영향. 대한한방소아과학회지. 2009;23(3):217-31.
11 구병삼. 임상 부인과 내분비학. 서울: 고려의학. 2001:228-31.
12 Wellman GC et al. Gender differences in coronary artery diameter involve estrogen, nitric oxide, and Ca2+-dependent K+ channels. Circ. Res. 1996;79: 1024-30.   DOI
13 Kopelman PG. Effects of obesity on fat topography: metabolic and endocrine determinants. In: Clinical Obesity(1st ed.), edited by Kopelman PG and Stock MJ. Oxford, UK: Blackwell Science. 1998:158-75.
14 Andreasen CH et al.. Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes, BMC Med Genet. 2009;10:17.
15 Li MD. Leptin and beyond: an odyssey to the central control of body weight. Yale J Biol Med. 2011;84(1):1-7.
16 Nakagami H, Morishita R. Obesity and gastrointestinal hormones-dual effect of angiotensin II receptor blockade and a partial agonist of PPAR-$\gamma$. Curr Vasc Pharmacol. 2011;9(2):162-6.   DOI
17 Pedersen SB et al.. Estrogen controls lipolysis by up-regulating alpha2A adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution. J. Clin. Endocrinol Metab. 2004;89:1869-78.   DOI
18 Jensen MD. Lipolysis: contribution from regional fat. Annu Rev Nutr. 1997;17:127-39.   DOI
19 Yamamoto T et al. A novel coenzyme A : diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity. Eur J Pharmacol. 2011;650(2-3):663-72.   DOI
20 이상봉, 금동호, 이명종. 비만의 원인과 치료에 대한 동서의학적 고찰. 한의학연구소논문집. 1996;5(1):33-52.
21 Matsuzawa Y et al. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24:29-33.   DOI
22 Zhang W et al. Leptin modulated changes in adipose tissue protein expression in ob/ob mice. Obesity (Silver Spring). 2011;19(2):255-61.   DOI