Browse > Article
http://dx.doi.org/10.4150/KPMI.2022.29.6.499

Fabrication and Evaluation of Powders Containing Calcium Silicate for Solid Self-emulsifying System of Oil  

Sung Giu, Jin (Department of Pharmaceutical Engineering, Dankook University)
Publication Information
Journal of Powder Materials / v.29, no.6, 2022 , pp. 499-504 More about this Journal
Abstract
The objective of this study is to assess the impact of spray drying conditions on medium-chain triglyceride (MCT) loading, solubility, and release of an MCT-loaded solid self-emulsifying system in a water-insoluble oily substance. MCT-loaded solid self-emulsifying systems are prepared by spray drying with SDS and calcium silicate. The effects of inlet temperature (60, 80, or 100℃) and feed solution composition (0, 10, 50, 90, or 100% ethanol) on physicochemical properties of MCT-loaded solid self-emulsifying systems are studied. The inlet temperature significantly affects the water solubility of MCT. Moreover, the feed solution composition significantly affects water solubility, release rate, and MCT loading. The MCT-loaded solid self-emulsifying system obtained at 60℃ using 90% ethanol feed solution shows the best physicochemical properties among the synthesized products and exhibits better water solubility (4.43 ± 0.44 vs. 0 ㎍/mL) and release (94.4 ± 1.6 vs. 32.8 ± 7.4%, 60 min) than a commercial product. Furthermore, the MCT-loaded solid self-emulsifying system shows an excellent emulsion droplet size (approximately 230 nm).
Keywords
Medium chain triglycerides; Solid self-emulsifying system; Spray drying; Release;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Y. Y. Lee, T. K. Tang, E. S. Chan, E. T. Phuah, O. M. Lai, C. P. Tan, Y. W. A. A. Karim, N. H. M. Dian and J. S. Tan: Crit. Rev. Food Sci. and Nutr., 62 (2022) 4169.   DOI
2 N. Buss, P. Ryan, T. Baughman, D. Roy, C. Patterson, C. Gordon and R. Dixit: J. Appl. Toxicol., 38 (2018) 1293.   DOI
3 K. I. Avgerinos, J. M. Egan, M. P. Mattson and D. Kapogiannis: Ageing Res. Rev., 58 (2020) 101001.   DOI
4 C. Von Corswant, P. Thoren and S. Engstrom: J. Pharm. Sci., 87 (1998) 200.   DOI
5 E. Jimenez-Martin, A. Gharsallaoui, T. Perez-Palacios, J. R. Carrascal and T. A. Rojas: Food Bioproc. Tech., 8 (2015) 100.   DOI
6 M. J. Choi, J. S. Kim, H. Yu, M. R. Woo, J. E. Choi, K. Baek, J. O. Kim, Y. S. Choi, H. G. Choi and S. G. Jin: J. Mol. Liq., 346 (2022) 117057.   DOI
7 E. J. Park, S. A. Choi, K. A. Min, J. P. Jee, S. G. Jin and K. H. Cho: Pharmaceutics, 14 (2022) 1694.   DOI
8 J. E. Choi, J. S. Kim, M. J. Choi, K. Baek, M. R. Woo, J. O. Kim, H. G., Choi and S. G. Jin: Int. J. Pharm., 597 (2021) 120377.   DOI
9 O. Mustapha, K. S. Kim, S. Shafique, D. S. Kim, S. G. Jin, Y. G. Seo, Y. S. Youn, K. T. Oh, B. J. Lee, Y. J. Park, C. S. Yong, J. O. Kim and H. G. Choi: Colloids Surf. B. Biointerfaces, 150 (2017) 216.   DOI
10 J. Mandic, A. Zvonar Pobirk, F. Vrecer and M. Gasperlin: Int. J. Pharm., 533 (2017) 335.   DOI
11 D. S. Kim, J. S. Kim, S. J. Lim, J. O. Kim, C. S. Yong, H. G. Choi and S. G. Jin: Pharmaceutics, 11 (2019) 415.   DOI
12 J. S. Kim, Y. J. Choi, M. R. Woo, S. Cheon, S. H. Ji, D. Im, F. U. Din, J. O. Kim, Y. S. Youn, K. T. Oh, S. J., Lim, S. G. Jin and H. G. Choi: Carbohydr. Polym., 271 (2021) 118433.
13 J. S. Kim, F. ud Din, Y. J. Choi, M. R. Woo, S. Cheon, S. H. Ji, S. Park, J. O. Kim, Y. S. Youn, S. J. Lim, S. G. Jin and H. G. Choi: Int. J. Pharm., 628 (2022) 122286.   DOI
14 I. Tntul and A. Topuz: Trends Food. Sci. Tech., 63 (2017) 91.
15 K. A. Fliszar, W. P. Wuelfing, Z. Li and R. A. Reed: J. Pharm. Biomed. Anal., 40 (2006) 896.   DOI
16 H. Yu, J. S. Kim, D. W. Kim, E. S. Park, Y. S. Youn, F. ud Din, J. O. Kim, Y. S. Youn, K. T. Oh, S. J. Lim, S. G. Jin and H. G. Choi: Compo. B. Eng., 225 (2021) 109276.   DOI
17 M. J. Choi, M. R. Woo, H. G. Choi and S. G. Jin: Int. J. Mol. Sci., 23 (2022) 9491.   DOI
18 FDA, (2012) Code of Federal Regulations, Title 21- Food and Drugs. Part 172 - Food additives permitted for direct addition to food for human consumption.
19 F. Wan and M. Yang: Int. J. Pharm., 498 (2016) 82.   DOI
20 A. Ziaee, A. B. Albadarin, L. Padrela, A. Faucher, E. O'Reilly and G. Walker: Eur. J. Pharm. Biopharm., 120 (2017) 43.   DOI
21 R. B. Nambiar, P. S. Sellamuthu and A. B. Perumal: Food Bioproc. Tech., 10 (2017) 1668.   DOI
22 S. Santhalakshmy, S. J. D. Bosco, S. Francis and M. Sabeena: Powder Technol., 274 (2015) 37.   DOI
23 K. S. Kim, S. G. Jin, O. Mustapha, A. M. Yousaf, D. W. Kim, Y. H. Kim, J. O. Kim, C. S. Yong, J. S. Woo and H. G. Choi: Int. J. Pharm., 490 (2015) 273.   DOI
24 A. M. Yousaf, O. Mustapha, D. W. Kim, D. S. Kim, K. S. Kim, S. G. Jin, C. S. Yong, Y. S. Youn, Y. K. Oh, J. O. Kim and H. G. Choi: Int. J. Nanomedicine, 11 (2016) 213.   DOI