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http://dx.doi.org/10.4150/KPMI.2007.14.2.127

Effect of Alumina Nanooxide Application on Nitrendipine Manufacturing Process  

Chae, E.J. (Department of Nuclear Nanomaterials Development Lab., Korea Atomic Energy Research Institute (KAERI))
Uhm, Y.R. (Department of Nuclear Nanomaterials Development Lab., Korea Atomic Energy Research Institute (KAERI))
Han, B.S. (Department of Nuclear Nanomaterials Development Lab., Korea Atomic Energy Research Institute (KAERI))
Rhee, C.K. (Department of Nuclear Nanomaterials Development Lab., Korea Atomic Energy Research Institute (KAERI))
Park, S.E. (Department of Physical Chemistry In-ha University)
Publication Information
Journal of Powder Materials / v.14, no.2, 2007 , pp. 127-131 More about this Journal
Abstract
The alumina nano powders synthesized by levitational gas condensation (LGC) method were applied to catalyst in manufacturing process of Hanzsch reaction for Nitrendipine. The L-tartaric acid on the surface is carried out with participation of carbonyl fragments, O-H, C-H bonds which affects stereo selectivity, yield on the reagents positively. From the analysis of the IR-spectroscopy, the carbonyl fragments, O-H, and C-H bond were created by the catalytic reaction. From the analysis of the rR-spectroscopy, the carbonyl fragments, O-H, and C-H bond were created by the catalytic reaction. The newly created bonds made a chiral center on the final product.
Keywords
Alumina oxide; Catalytic effect; Chiral modifier;
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