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http://dx.doi.org/10.7234/kscm.2008.21.3.018

Manufacturing and in vitro Characterization of Composite Drug Delivery System (DDS)  

Chu, Won-Shik (서울대학교 기계항공공학부 대학원)
Jeong, Suk-Yong (서울대학교 기계항공공학부 대학원)
Park, Jeong-Bin (서울대학교 기계항공공학부 대학원)
Ahn, Sung-Hoon (서울대학교 기계항공공학부, 서울대학교 정밀기계공동연구소)
Lee, Jae-Hoon (성균관대학교 약학부)
Chi, Sang-Chul (성균관대학교 약학부)
Publication Information
Composites Research / v.21, no.3, 2008 , pp. 18-23 More about this Journal
Abstract
The Rapid Prototyping (RP) technology has advanced in many application areas. In this research, implantable Drug Delivery System (DDS) was fabricated by an RP system, Nano Composite Deposition System (NCDS). The DDS composite consists of 5-fluorouracil (5-FU), as drug particles, and PLGA85/15 as biodegradable polymer matrix. To have larger surface area, the DDS was fabricated in a scaffold shape, and its degradation was tested in vitro environment. Biocompatible Hydroxyapatite (HA) powders were added to the drug-polymer composite in order to control drug release. Test results showed a possibility of controlled release of scaffold DDS over 50 days.
Keywords
Rapid Prototyping; Scaffold; Hydroxyapatite; Drug-polymer Composite;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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