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http://dx.doi.org/10.22650/JKCNR.2017.23.1.120

Menopausal Symptoms and Associated Factors in Breast Cancer Patients Receiving Hormone Therapy  

Kim, Younglan (College of Nursing, Dankook University)
Min, Yul Ha (College of Nursing, Dankook University)
Publication Information
Abstract
Purpose: The purpose of this study was to identify the degree of menopause symptoms and associated factors in patients with breast cancer who were receiving hormone therapy. Methods: Data were collected with questionnaires from 150 patients with breast cancer who had been on hormone therapy at a hospital in Seoul. Data were analyzed with the t-test, ANOVA, and Pearson correlation coefficient to compare the degree of menopause symptoms by demographic, clinical and psychological factors. Results: The mean menopause symptoms score was $13.39{\pm}7.97$. Most participants reported having hot flushes and sweating (75.3%), physical and mental exhaustion (82.7%) and sexual problems (64.7%). Menopause symptoms and depression were correlated with each other (p<.01). Somato-vegetative symptoms were different significantly by age, menopausal status at time of operation, occupation and tumor. Psychological symptoms were different significantly by marital status, operation type and chemotherapy. Urogenital symptoms were different significantly by prior history of cancer, occupation, operation type and radiation therapy. Conclusion: These findings can be used to provide tailored nursing interventions by identifying high risk groups for menopausal symptom among breast cancer patients receiving hormone therapy.
Keywords
Breast Neoplasms; Hormonal Antineoplastic Agents; Menopause; Medication Adherence; Depression;
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1 National Cancer Information Center. National cancer statistics 2014 [Internet].Gyeonggi:National Cancer Information Center; 2014 [cited 2017 January 5]. Available from: l.mbs/cancer/subview.jsp?id=cancer.
2 Grunfeld EA, Hunter MS, Sikka P, Mittal S. Adherence beliefs among breast cancer patients taking tamoxifen. Patient Education Counseling. 2005;59(1):97-102.   DOI
3 Gupta P, Sturdee DW, Palin SL, Majumder K, Fear R, Marshall T, et al. Menopausal symptoms in women treated for breast cancer: the prevalence and severity of symptoms and their perceived effects on quality of life. Climacteric. 2006;9(1):49-58.   DOI
4 Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Applied Psychological Measurement. 1977;1(3):385-401.   DOI
5 Cho MJ, Nam JJ, Suh GH. Prevalence of symptoms of depression in a nationwide sample of Korean adults. Psychiatry Research. 1998;81(3):341-352.   DOI
6 Bordeleau L, Pritchard K, Goodwin P, Loprinzi C. Therapeutic options for the management of hot flashes in breast cancer survivors: an evidence-based review. Clinical Therapeutics. 2007;29(2):230-241.   DOI
7 Ganz PA, Greendale GA, Petersen L, Zibecchi L, Kahn B, Belin TR. Managing menopausal symptoms in breast cancer survivors: results of a randomized controlled trial. Journal of the National Cancer Institute. 2000;92(13):1054-1064.   DOI
8 Kroenke K. Patients presenting with somatic complaints: epidemiology, psychiatric co-morbidity and management. International Journal of Methods in Psychiatric Research. 2003;12(1):34-43.   DOI
9 Cluze C, Rey D, Huiart L, BenDiane MK, Bouhnik AD, Berenger C, et al. Adjuvant endocrine therapywith tamoxifen in young women with breast cancer: determinants of interruptions vary over time. Annals of Oncology. 2012;23(4):882-890.   DOI
10 Gotay C, Dunn J. Adherence to long-termadjuvant hormonal therapy for breast cancer. Expert Reviewof Pharmacoeconomics & Outcomes Research. 2011;11(6):709-715. http://dx.doi.org/10.1586/erp.11.80
11 Hwang E, Yi M. Factors influencing quality of life in patients with breast cancer on hormone therapy. Journal of Korean Academy of Nursing. 2014;44(1):108-117. http://dx.doi.org /10.4040/jkan.2014.44.1.108   DOI
12 Korean Breast Cancer Society. The breast. 2nd ed. Seoul: Ilchokak Publishing Co; 2005.
13 Dorjgochoo T, Gu K, Kallianpur A, Zheng Y, Zheng W, Chen Z, et al. Menopausal symptoms among breast cancer patients 6 months after cancer diagnosis: a report from the Shanghai Breast Cancer Survival Study(SBCSS). Menopause. 2009;16(6):1205-1212.   DOI
14 Mols F, Vingerhoets AJ, Coebergh JW, van de Poll-Franse LV. Quality of life among long-term breast cancer survivors: a systematic review. European Journal of Cancer. 2005;41(17):2613-2619.   DOI
15 Harris PF, Remington PL, Trentham-Dietz A, Allen CI, Newcomb PA. Prevalence and treatment of menopausal symptoms among breast cancer survivors. Journal of pain and symptom management. 2002;23(6):501-509.   DOI
16 Korean Breast Cancer Society. Breast Cancer Facts & Figures 2016. Seoul: Korean Breast Cancer Society, 2016. p. 1-21.
17 Ganz PA. Breast cancer, menopause, and long-termsurvivorship: critical issues for the 21st century. The American Journal of Medicine. 2005;118(12):136-141.   DOI
18 Cappiello M, Cunningham RS, Knobf MT, Erdos D. Breast cancer survivors information and support after treatment. Clinical Nursing Research. 2007;16(4):278-293.   DOI
19 Luber MP, Meyers BS, Williams-Russo PG, Hollenberg JP, DiDomenico TN, Charlson ME, et al. Depression and service utilization in elderly primary care patients. The American Journal of Geriatric Psychiatry. 2001;9(2):169-176.   DOI
20 Fontaine C, Meulemans A, Huizing M, Collen C, Kaufman L, DeMey J, et al. Tolerance of adjuvant letrozole outside of clinical trials. The Breast. 2008;17(4):376-381.   DOI
21 Bower JE, Ganz PA, Desmond KA, Rowland JH, Meyerowitz BE, Belin TR. Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. Journal of Clinical Oncology. 2000;18(4):743-753.   DOI
22 Mausbach BT, Schwab RB, Irwin SA. Depression as a predictor of adherence to adjuvant endocrine therapy(AET) in women with breast cancer: a systematic review and meta-analysis. Breast Cancer Research and Treatment. 2015;152(2):239-246. http://dx.doi.org/10.1007/s10549-015-3471-7   DOI
23 Savard J, Simard S, Blanchet J, Ivers H, Morin CM. Prevalence, clinical characteristics, and risk factors for insomnia in the context of breast cancer. Sleep. 2001;24(5):583-590.   DOI
24 Barsevick AM, Whitmer K, Nail LM, Beck SL, Dudley WN. Symptom cluster research: conceptual, design, measurement, and analysis issues. Journal of Pain and Symptom Management. 2006;31(1):85-95.   DOI
25 Byar KL, Berger AM, Bakken SL, Cetak MA. Impact of adjuvant breast cancer chemotherapy on fatigue, other symptoms, and quality of life. Oncology Nursing Forum; 2006;33(1):18-26.   DOI
26 Avis NE, Crawford S, Manuel J. Psychosocial problems among younger women with breast cancer. Psycho-Oncology. 2004;13(5):295-308.   DOI
27 Yang YH. Trajectory of fatigue, quality of life and physical symptoms in cancer patients receiving radiotherapy. Journal of Korean Academy of Nursing. 2003;33(5):562-569.   DOI
28 Heinemann K, Ruebig A, Potthoff P, Schneider HP, Strelow F, Heinemann LA. The Menopause rating scale(MRS) scale: a methodological review. Health and quality of life Outcomes. 2004;2(1):1-8.   DOI
29 Vahdaninia M, Omidvari S, Montazeri A. What do predict anxiety and depression in breast cancer patients? A follow-up study. Social Psychiatry and Psychiatric Epidemiology. 2010;45(3):355-361. http://dx.doi.org/10.1007/s00127-009-0068-7   DOI
30 Moon JM. Menopause symptoms, fatigue, and quality of life in post-chemotherapy breast cancer survivors [dissertation]. Seoul: Yonsei University. 2009. p. 1-108.