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http://dx.doi.org/10.5806/AST.2021.34.6.267

Validation of acid-base titration equivalence between spectroscopic titrator (SPT) and conventional titrators  

Shin, Jiwon (Division of Life-Science and Chemistry, Daejin University)
Kim, Yeajin (Division of Life-Science and Chemistry, Daejin University)
Lee, Hyoseong (Division of Life-Science and Chemistry, Daejin University)
Shin, Jisun (Division of Life-Science and Chemistry, Daejin University)
Yoo, Hyein (Division of Life-Science and Chemistry, Daejin University)
Chae, Won-Seok (Division of Life-Science and Chemistry, Daejin University)
Publication Information
Analytical Science and Technology / v.34, no.6, 2021 , pp. 267-274 More about this Journal
Abstract
Acid-base titration experiments were carried out using the same sample to obtain a direct comparison of analysis results between a new titrator and conventional Spectrator (SPT) titrators. This allowed the confirmation of an endpoint both by spectroscopic detection and by conventional titrators (automatic burette (ABT) and autotitrator (ATT)). Statistical analysis was performed on the measured values (endpoints) obtained using different titrators, to assess their differences by comparison of straightness, equivalence, ANOVA, F-test, and t-test results. The coefficients of determination, confirmed by straightness, were all >0.999. Thus, the null hypothesis that there was no statistical difference could not be rejected. The Bland-Altman analysis method was used to confirm agreement with the new experimental method. No discrepancy was found in the measured values obtained using different titrators used in this study.
Keywords
automatic burette; autotitrator; spectrator; statistic analysis; bland-altman plot;
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  • Reference
1 S.L.R. Ellison and A. Williams, 'Quantifying Uncertainty in Analytical Measurement', EURACHEM/ CITAC Guide, 3rd Ed., 2012.
2 D. C. Harris, 'Quantitative Chemical Analysis', 9th Ed., W.H. Freeman, New York, 2016.
3 공경애, "검사법 평가: 검사법 비교와 신뢰도 평가", Ewha Med. J., 40(1), 9-16 (2017).   DOI
4 D.A.A. Forigua and J. Meija, Anal. Bioanal. Chem., 411, 1-2 (2019).   DOI
5 F.G. Page, Bull. Hist. Chem., 26(1), 66-72 (2001).
6 A. Johansson, Anal. Chim. Acta, 206, 97-109 (1988).   DOI
7 F. Szabadvary, 'History of Analytical Chemistry: International Series of Monographs in Analytical Chemistry', Elsevier, 2016.
8 D.A. Skoog, D.M. West, F.J. Holler and S.R. Crouch, 'Fundamentals of Analytical Chemistry', 9th Ed., Cengage Learning, Boston, 2014.
9 J. Shin, G. Chae, Y. Kim, S. Kim, Y. Chae and W.S. Chae, Anal. Sci. Technol., 34(3), 128-133 (2021).   DOI
10 J. Yen, D. Leber and L. Pibida, 'Comparing Instruments', NIST Technical Note 2106, 2020.
11 https://en.wikipedia.org/wiki/Bland-Altman_plot
12 J.M. Bland and D.G. Altman, J. Biopharm. Stat., 17, 571-582 (2007).   DOI