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http://dx.doi.org/10.5806/AST.2016.29.4.162

Comparative bioavailability of synthetic vitamin C and Nutra-C (calcium ascorbate) in Korean healthy volunteers  

Choi, Kyung-Mi (CELLTRION PHARM, Inc.)
Hoon, Kim Man (CELLTRION PHARM, Inc.)
Won, Hwang Tae (CHEIL Co., LTD.)
Kim, Jong-Dae (SUHEUNG Co.)
Park, Keum duck (SUHEUNG Co.)
Kim, Mi-Young (Seoul Pharma Laboratories, CrystalGenomics Inc.)
Jung, Young-Rim (Seoul Pharma Laboratories, CrystalGenomics Inc.)
Shin, Hye-Seoung (Seoul Pharma Laboratories, CrystalGenomics Inc.)
Publication Information
Analytical Science and Technology / v.29, no.4, 2016 , pp. 162-169 More about this Journal
Abstract
The purpose of this study was to compare the relative bioavailability of synthetic Vitamin C and Nutra-C® (calcium ascorbate) using a randomized parallel pharmacokinetics study design. Under fasting conditions, 20 healthy volunteers were randomly allocated to receive a single oral dose (500 mg of ascorbic acid) of either synthetic Vitamin C or Nutra-C®. Fasting blood was collected pre-dose and 1, 2, 3, 4, 7 and 10 hr post-dose. The ascorbic acid content of human serum was determined using HPLC with ultraviolet detection. The fasting serum ascorbic acid concentrations of synthetic Vitamin C and Nutra-C® were 6.734 ± 2.09 ng/mL (n = 10) and 7.542 ± 2.96 ng/mL (n = 10), respectively. The bioavailability of Nutra-C® was significantly greater (128 %, p < 0.05) than that of the synthetic Vitamin C.
Keywords
Vitamin C; Nutra-C; Bioavailability; Human serum;
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1 Y. Li and H. E. Schellhorn, Br. J. Nutr., 137, 2171-2184 (2007).
2 A. C. Carr and B. Frei, Am. J. Clin. Nutr., 69, 1086-1107 (1999).
3 A. R. Tricker and R. Preussmann, Mutat. Res., 259, 277-289 (1991).   DOI
4 R. A. Scanlan, Nitrosamines and cancer. Linus Pauling Institute website. http://lpi.oregonstate.edu/f-w00/nitrosamine.html (2000).
5 National Institutes of Health (NIH), Office of Dietary Supplements. Vitamin C. Dietary Supplement Fact Sheet. http://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/ (2013).
6 K. Beck, C. A. Conlon, R. Kruger and J. Coad and W. Stonehouse, Br. J. Nutr., 105, 101-109 (2011).   DOI
7 L. Hallberg, M. Brune and L. Rossander, Hum. Nutr. Appl. Nutr., 40, 97-113 (1986).
8 N. M. Scheers and A. S. Sandberg, Br. J. Nutr., 105, 1734-1740 (2011).   DOI
9 C. J. Bates, K. S. Jones and L. J. Bluck, Br. J. Nutr., 91, 699-705 (2004).   DOI
10 A. R. Mangels, G. Block, C. M. Frey, B. H. Patterson, P. R. Taylor, E. P. Norkus and O. A. Levander, J. Nutr., 123, 1054-1061 (1993).
11 F. R. Keltz, C. Kies and H. M. Fox, Am. J. Clin. Nutr., 31, 1167-1171 (1978).
12 J. N. Hathcock, A. Azzi, J. Blumberg, T. Bray, A. Dickinson, B. Frei, I. Jialal, C. S. Johnston, F. J. Kelly and K. Kraemer, Am. J. Clin. Nutr., 81, 736-745 (2005).
13 M. Levine, C. Conry-Cantilena, Y. Wang, R. W. Welch, P. W. Washko, K. R. Dhariwal, J. B. Park, A. Lazarev, J. F. Graumlich and J. King, Proc. Natl. Acad. Sci., 93, 3704-3709 (1996).   DOI
14 S. Yung, M. Mayersohn and J. B. Robinson, J. Pharm. Sci., 71, 282-285 (1982).   DOI
15 H. N. Bhagavan and B. I. Wolkoff, Pharm. Res., 10, 239-242 (1993).   DOI
16 R. Sacharin, T. Taylor and L. F. Chasseaud, Int. J. Vitam. Nutr. Res., 47, 68-74 (1977).
17 K. Nyyssonen, H. E. Poulsen, M. Hayn, P. Agerbo, E. Porkkala-Sarataho, J. Kaikkonen, R. Salonen and J. T. Salonen, Eur. J. Clin. Nutr., 51, 154-163 (1997).   DOI
18 M. J. Bush and A. J. Verlangieri, Res. Commun. Chem. Pathol. Pharmacol., 57, 137-140 (1987).
19 A. J. Verlangieri, M. J. Fay and A. W. Bannon, Life Sci., 48, 2275-2281 (1991).   DOI
20 C. S. Johnston and B. Luo, J. Am. Diet. Assoc., 94, 779-781 (1994).   DOI
21 J. Gruenwald, H. J. Graubaum, R. Busch and C. Bentley, Adv. Ther., 23, 171-178 (2006).   DOI
22 M. S. Şerban, Gh. Câmpeanu and E. Ionescu, Metode de Laborator ín Biochimia Animală , Editura Didactica si Pedagogica, Bucuresti, Romania, 1993.
23 C. Cofan and C. Radovan, Sensors, 8, 3952-3969 (2008).   DOI
24 C. Papuc, A. Pop and M. Şerban, Metode Analitice in Biochimia Veterinara, Editura Printech, Bucuresti, Romania, 2001.
25 D. Balan, M. Pele, M. Artimon and G. Luta, “Bioactive compounds in sea buckthorn fruits and in some products obtained by their processing”, Revue de Cytologie et de Biologie Végétales-Le Botaniste, 28, 364-368 (2005).
26 N. Matei, V. Magearu, S. Birghilă , and S. Dobrinaş, Revista de Chimie, 55(5), 294-296 (2004).
27 L. G. Shaidarova, A. V. Gedmina, I. A. Chelnokova and G. K. Budnikov, J. Anal. Chem., 61, 601-608 (2006).   DOI
28 Y. Wang, H. Xu, J. M. Zhang and G. Li, Sensors, 8, 2043-2081 (2008).   DOI
29 U. Yogeswaran and S. M. Chen, Sensors, 8, 290-313 (2008).   DOI
30 J. Chen and Y. J. Fang, Sensors, 7, 448-458 (2007).
31 R. C. Matos, M. A. Augelli, C. L. Lago and L. Angnes, Anal. Chim. Acta, 404, 151-157 (2000).   DOI
32 P. Janda, J. Weber, L. Dunsch and A. B. P. Lever, Anal. Chem., 68, 960-965 (1996).   DOI
33 W. A. Behrens and R. Madere, Anal. Biochem., 165, 102-107 (1987).   DOI
34 R. Shakya and D. A. Navarre, J. Agric. Food Chem., 54, 5253-5260 (2006).   DOI
35 A. J. Melendez-Martinez, I. M. Vicario and F. J. Heredia, Food Chem., 101, 177-184 (2007).   DOI
36 J. Wang, M. P. Chatrathi, B. M. Tian and R. Polsky, Anal. Chem., 72, 2514-2518 (2000).   DOI
37 M. W. Davey, G. Bauw and M. VanMontagu, J. Chromatogr. B, 697, 269-276 (1997).   DOI
38 M. A. Kall and C. Andersen, J. Chromatogr. B, 730, 101-111 (1999).   DOI
39 B. Klejdus, J. Petrlova, D. Potesil, V. Adam, R. Mikelova, J. Vacek, R. Kizek and V. Kuban, Anal. Chim. Acta, 520, 57-67 (2004).   DOI
40 T. Wu, Y. Q. Guan and J. N. Ye, Food Chem., 100, 1573-1579 (2007).   DOI
41 E. J. Oliveira and D. G. Watson, J. Chromatogr. B, 764, 3-25 (2001).   DOI
42 H. Iwase and I. Ono, J. Chromatogr A, 806(2), 361-364 (1998).   DOI