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http://dx.doi.org/10.5806/AST.2014.27.6.333

Validation of analysis of urinary fluoride by ion selective electrode method  

Lee, Mi-Young (Korea Occupational and Health Agency, Industrial Safety and Health Research Institute)
Yoo, Kye-Mook (Korea Occupational and Health Agency, Industrial Safety and Health Research Institute)
Publication Information
Analytical Science and Technology / v.27, no.6, 2014 , pp. 333-338 More about this Journal
Abstract
A simple and sensitive analytical method for fluoride in urine by ion selective electrode (ISE) method was presented. Traditional buffer for fluoride determination using ISE is acetate-based one. Researchers have pointed out some drawbacks of the buffer for fluoride ISE analysis, and some other buffers including citrate-ammonium buffer and MES buffer have been studied for accurate determination of fluoride in urine here. These buffers provided promising results in environmental field, and this author focused on overcoming the interference of co-existing aluminium. The results show that MES-CyDTA buffer gave the best recovery with accuracy of 95-97.5% and precision of 1.9-7.9% for reference sample of 1.8-7.8 mg/L fluoride in urine, with smaller amount of samples and shorter analysis time compared with the traditional method which used acetate buffer. The method was applied to field samples, and which showed urinary of $0.98{\pm}0.38mg/g$ creatinine for workers in electric cable manufacturing factory (n=15) and $0.59{\pm}0.30mg/g$ creatinine for non-exposed workers (n=12).
Keywords
urinary fluoride; biological monitoring; ion selective electrode; MES-CyDTA buffer;
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1 K. H. Schaller and J. Angerer, 'Analysis of hazardous substances in biological materials: Methods for biological monitoring', Vol. 2. New York: VCH Publishers (1988).
2 J. S. Park, 'Practical guide of health examination of workers', Vol. 3, p 473, Occupational safety and research Institute, Incheon, 2013.
3 Y. J. Kim, S. H. Park and K. S. Choi, J. Korean Ophthalmol. Soc., 54(11), 1663-1668 (2013).   DOI
4 H. K. Pak, 'Case report on accident of hydrofluoric acid leakage', Korea occupational safety and health agency, Incheon, 2013.
5 Y.-Y. Kang, Y.-J. Kim, W.-I. Kim, C.-W. Yoon, J.-M. Yeon, S.-K. Shin and G.-J. Oh, Anal. Sci. Technol., 27(3), 167-171 (2014).   DOI   ScienceOn
6 S. lehtinen, 'Biological monitoring of chemical exposure in the workplace', Vol. 2, Geneva, World Health Organization, 1996.
7 M. Rietjens, Anal. Chim. Acta, 368, 265-273 (1998).   DOI   ScienceOn
8 M. Fouskaki, S. Sotiropoulou, M. Koci and N. A. Chaniotakis, Anal. Chim. Acta, 478(1), 77-84 (2003).   DOI   ScienceOn
9 M. Trojanowicz, P. W. Alexander and D. B. Hibbert, Anal. Chim. Acta, 366(1-3), 23-33 (1998).   DOI   ScienceOn
10 K. Itai and H. Tsunoda, Clin. Chim. Acta, 308(1), 163-171 (2001).   DOI   ScienceOn
11 J.-S. Yang, 'Biological monitoring of workers exposed to organic solvent mixture or inorganic chemical: Proficiency test for samples of biological monitoring', Occupational safety and research Institute, Incheon, 1995.
12 American Conference of Governmental Industrial Hygienists (ACGIH), 'Threshold Limit Values for Chemical Substances and Physical Agents & Biological Exposure Indices with 7th Edition Documentation', Cincinnati, 2013.
13 Instruction for exposure and analysis (2010.3.11), Finland, http://www.ttl.fi/fi/asiantuntijapalvelut/tyoymparisto/kemikaalit_ja_polyt/biomonitorointi/naytteenotto/Documents/UF.pdf, 2010.
14 J. Eckstrand, C. J. Spak and M. Ehrnebo, Acta Pharmacol. Toxicol., 50, 321-325 (1982).