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http://dx.doi.org/10.5806/AST.2014.27.5.228

Fabrication and characterization of block copolymer (PCL/PCL-PEG) nanofibers binding with collagen by electrospun  

Lee, Jin Woo (Department of Chemistry, College of life Science and Nano Technology, Hannam University)
Yoon, Kuk Ro (Department of Chemistry, College of life Science and Nano Technology, Hannam University)
Publication Information
Analytical Science and Technology / v.27, no.5, 2014 , pp. 228-233 More about this Journal
Abstract
Electrospun polymeric nanofibers have been extensively studied for biomedical materials because of their unique structures and relatively easy fabrication with biocompatible polymers. The amount of surface exposed amine groups increases as the blend ratio of block copolymer increases. Cell attachments on the nanofibers change according to the ratio of the block copolymer ((Poly(e-caprolactone, PCL), Poly(e-caprolactone)-Poly (ethylen glycol-$NH_2$)) in the blend. We assume that the PEG and amine moiety plays a significant role in biocompatibility of nanofiber surfaces. Collagen was used as a grafting material on the composite nanofibers to enhance the cell adhesion because the collagen is a major constituent of connective tissue.
Keywords
Block copolymer (PCL/PCL-PEG); Nanofiber; collagen; biocompatibility; cell adhesion;
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