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http://dx.doi.org/10.5806/AST.2010.23.5.457

The analysis of pharmaceuticals in drinking water by HPLC/ESI-MS/MS  

Park, Mi-Sun (Department of Chemistry, Kyonggi University)
Kim, Byung-Joo (Department of Chemistry, Kyonggi University)
Myung, Seung-Woon (Department of Chemistry, Kyonggi University)
Publication Information
Analytical Science and Technology / v.23, no.5, 2010 , pp. 457-464 More about this Journal
Abstract
The analytical method of four pharmaceuticals (virginiamycin, erythromycin, tylosin and cimetidine) in drinking water was developed. Effective simultaneous sample clean-up and extraction by solid-phase extraction (SPE) using HLB cartridge prior to LC/ESI-MS/MS analysis were performed. A linear correlation observed in the calibration curves for drinking water in the range of 0.01~2.0 ng/mL showed above $r^2$=0.995. Absolute recovery was in the range of 64.7~118.1% (except cimetidine (37.7~48.1%)). Limit of detection (LOD) and limit of quantitation (LOQ) in spiked drinking water matrix were in the range of 1.6~74.8 pg/mL and 5.5~249.7 pg/mL, respectively. The established method can be used to determine low pg/mL levels of pharmaceuticals in the drinking water.
Keywords
macrolides; cimetidine; drinking water; LC/ESI-MS/MS;
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