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http://dx.doi.org/10.5806/AST.2010.23.2.119

Simultaneous analysis of β-lactam antibiotics in surface water  

Huh, Min-Jeong (Department of Chemistry, Kyonggi University)
Myung, Seung-Woon (Department of Chemistry, Kyonggi University)
Publication Information
Analytical Science and Technology / v.23, no.2, 2010 , pp. 119-127 More about this Journal
Abstract
An effective method for the simultaneous analysis of ${\beta}$-lactams from surface water was established. After solid-phase extraction with HLB (Hydrophilic Lipohilic Balance) cartridge at pH 2, seven ${\beta}$-lactams (amoxicillin, ampicillin, penicillin G, cefaclor, cefadroxil, cefatrizine and cephradine) were determined using LC/ESI-MS/MS. In this newly established method, correlation coefficients ($r^2$) of calibration curves for seven ${\beta}$-lactams in blank surface water appeared to be 0.9911~0.9995 in the concentration range of 0.01~1.0 ng/mL. The limits of detection (LODs) and the limits of quantificaiton (LOQs) in spiked surface water were shown to be 0.0003~0.0234 ng/mL and 0.0046~0.0778 ng/mL, respectively. The developed method is believed to serve as a rapid and reliable method for the qualitative and quantitative analysis of residual ${\beta}$-lactam antibiotics from aquatic environment.
Keywords
${\beta}$-lactam; surface water; LC/MS/MS; residual analysis;
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