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http://dx.doi.org/10.5806/AST.2010.23.1.054

Simultaneous determination of parabens in cosmetics by LC/MS  

Park, Gyo-Beom (Center for Chemical Analysis, Korea Research Institute of Chemical Technology)
Lee, Sueg-Geun (Center for Chemical Analysis, Korea Research Institute of Chemical Technology)
Publication Information
Analytical Science and Technology / v.23, no.1, 2010 , pp. 54-59 More about this Journal
Abstract
The simultaneous analysis of parabens in cosmetic samples was carried out by LC/MS. The cosmetic samples are directly dissolved in methanol and filterated using $0.45\;{\mu}m$ filter. The methanol-water was used for the mobile phase of gradient conditions. An Extend $C_{18}$ reverse-phase column and the selected ion monitoring (SIM) mode were applied. The analysis results of LC/MS showed good linearity with correlation coefficient of $r^2$=0.9993 in the range of 0.05 to $10\;{\mu}g$/mL and detection limit of $0.01\;{\mu}g$/mL.
Keywords
paraben; LC/MS;
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