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http://dx.doi.org/10.5806/AST.2009.22.3.210

Simultaneous determination of amphetamine derivatives and norketamine in hair by GC-MS/MS  

Kim, Jin Young (Drug Analysis Laboratory, Supreme Prosecutors' Office)
Shin, Soon Ho (Drug Analysis Laboratory, Supreme Prosecutors' Office)
Ko, Beom Jun (Drug Analysis Laboratory, Supreme Prosecutors' Office)
Chung, Jae Cheol (Drug Analysis Laboratory, Supreme Prosecutors' Office)
Suh, Yong Jun (Drug Analysis Laboratory, Supreme Prosecutors' Office)
In, Moon Kyo (Drug Analysis Laboratory, Supreme Prosecutors' Office)
Publication Information
Analytical Science and Technology / v.22, no.3, 2009 , pp. 210-218 More about this Journal
Abstract
A gas chromatography-tandem mass spectrometry (GC-MS/MS) method was developed and validated for simultaneous determination of amphetamine derivatives and norketamine in human hair. Preparation of hair involves external decontamination, mechanical pulverization, incubation and extraction prior to instrumental analysis. The samples were derivatized using heptafluorobutyric anhydride, and analyzed by GC-MS/MS. The linear ranges were 0.05-20.0 ng/mg for the analytes except for 3,4-methylenedioxyamphetamine, with good coefficients of determination ($r^2$ >0.998). The intra-day and inter-day precisions were within 10.7% and 8.5%, respectively. The intra-day and inter-day accuracies were between -1.6 and 17.0% and -2.6 and 10.5%, respectively. The limits of detections for each analyte were lower than 0.007 ng/mg, while recoveries were 75.9-100.9%. When the method was applied to hair samples obtained from suspected drug abusers, the concentrations in hair samples were 0.97-19.30 ng/mg for methamphetamine and 0.14-2.56 ng/mg for amphetamine.
Keywords
Amphetamine derivatives; norketamine; GC-MS/MS; hair;
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