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http://dx.doi.org/10.5806/AST.2008.21.3.191

Determination of acidic pharmaceuticals in aquatic environmental samples by LC/ESI-MS/MS  

Sim, Young-Eun (Dept. of Chemistry, Kyonggi University)
Cho, Hyun-Woo (Dept. of Chemistry, Kyonggi University)
Myung, Seung-Woon (Dept. of Chemistry, Kyonggi University)
Publication Information
Analytical Science and Technology / v.21, no.3, 2008 , pp. 191-200 More about this Journal
Abstract
Pharmaceuticals and personal care products (PPCPs) are emerging contaminants in aquatic environmental samples. Therefore, it required rapidly and certainly analytical method for pharmaceuticals which are existed in environment. In this study, Liquid chromatography/tandem mass spectrometry (LC-MS/MS) with electrospray ionization (ESI) was used to measure the concentrations of 7 pharmaceuticals (quinoxaline-2-carboxylic acid, acetylsalicylic acid, diclofenac-Na, naproxen, ibuprofen, mefenamic acid, talniflumate) from environmental water or aquatic samples simultaneously. Effective sample clean-up by solid-phase extraction (SPE) prior to LC-MS/MS analysis is necessary. For further purification, Mixed Cation eXchange (MCX) and Hydrophilic-Lipophilic Balance (HLB) solid-phase extraction (SPE) cartridges were used to eliminate the remaining interferences. LODs (Limits of Detection) and MDLs (Method Detection Limits) for the spiked sample in fresh water were in the range of 0.05~1.50 pg/mL and 0.17~4.90 pg/mL, respectively. The absolute recovery in the concentration of 1.0 ng/mL were between 81.9 and 116.3%. The acidic pharmaceuticals were detected in concentrations of 0.018~16.925 ng/mL in aquatic environmental samples.
Keywords
acidic pharmaceuticals; aquatic environmental samples; LC/ESI-MS/MS;
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