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http://dx.doi.org/10.5806/AST.2008.21.1.034

Determination of lercanidipine in human plasma by LC-MS/MS  

Jang, Moon-Sun (Drug Development Supporting Service Division, BioCore Co., Ltd.)
La, Sookie (Drug Development Supporting Service Division, BioCore Co., Ltd.)
Chang, Kyu Young (Drug Development Supporting Service Division, BioCore Co., Ltd.)
Kang, Seung Woo (Drug Development Supporting Service Division, BioCore Co., Ltd.)
Han, Sang Beom (College of Pharmacy, ChungAng University)
Lee, Kyung Ryul (Drug Development Supporting Service Division, BioCore Co., Ltd.)
Lee, Hee Joo (Drug Development Supporting Service Division, BioCore Co., Ltd.)
Publication Information
Analytical Science and Technology / v.21, no.1, 2008 , pp. 34-40 More about this Journal
Abstract
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantitative determination of lercanidipine in human plasma. After addition of internal standard (amlodipine), plasma was precipitated with acetonitrile and the supernatant was evaporated. The residues were dissolved in 50 % acetonitrile and analyzed by LC-MS/MS. Using MS/MS with multiple reaction monitoring(MRM) mode, lercanindipine were selectively detected without severe interference from human plasma. The standard calibration curve for lercanidipine was linear (r = 0.9994) over the concentration range 0.05-20.0 ng/mL in human plasma. The intra- and inter-day precision over the concentration range of lercanidipine was lower than 11.7 % (correlation of variance, CV), and accuracy was between 94.4-114.8 %. This method has been successfully applied to the pharmacokinetic study of lercanidipine in human plasma.
Keywords
lercanidipine; LC-MS/MS; pharmacokinetic study;
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