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http://dx.doi.org/10.5806/AST.2007.20.4.339

Molecular holographic QSPR analysis on the reactivity between glycine and ninhydrin analogues as latent fingerprints detector  

Kim, Se-Gon (Dept. of Applied Biology and Chemistry, Chungnam National University)
Jang, Seok-Chan (Dept. of Applied Biology and Chemistry, Chungnam National University)
Cho, Yun-Gi (Dept. of Applied Biology and Chemistry, Chungnam National University)
Hwang, Tae-Yeon (Dept. of Applied Biology and Chemistry, Chungnam National University)
Park, Sung-Woo (Dept. of Scientific Criminal Investigation, Chungnam National University)
Sung, Nack-Do (Dept. of Applied Biology and Chemistry, Chungnam National University)
Publication Information
Analytical Science and Technology / v.20, no.4, 2007 , pp. 339-346 More about this Journal
Abstract
To search the ninhydrin derivatives that have high chromogenic and fluorogenic properties, molecular holographic quantitative structure property relationship (HQSPR) models on the reactivity between glycine and ninhydrin analogues as latent fingerprint detector were derived and investigated quantitatively. The ${\varepsilon}LUMO$ (e.v.) energy of ninhydrin molecule was an important factor to reactivity of ninhydrin. And, it is suggested that the nucleophilic reaction by orbital-controlled reaction from the frontier molecular orbital (FMO) interaction between glycine and ninhydrin derivatives was more superior than that of electrophilic reaction by charged controlled reaction. The analytical results in atomic contribution maps also shows that the reactivity of ninhydrin was increased by meta-substituents as strong electron withdrawing groups on the benzo ring. Therefore, it is sugested by HQSPR and QSPR model that the 5,6-dinitroninhydrin molecule would increase the reactivity as much as three times as compared to none substituted ninhydrin molecule.
Keywords
Latent fingerprint detector; ninhydrin analogues; FMO interaction; ${\varepsilon}LUMO$ energy; HQSPR analysis;
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