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http://dx.doi.org/10.5806/AST.2007.20.3.204

Study on the confirmation of drinking at the bloods & urines used 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol  

Kim, Myung-Duck (National Institute of Scientific Investigation)
Kim, Young-Woon (National Institute of Scientific Investigation)
Kwon, O-Sung (National Institute of Scientific Investigation)
Park, Se-Youn (National Institute of Scientific Investigation)
Kim, Eun-Ho (National Institute of Scientific Investigation)
Publication Information
Analytical Science and Technology / v.20, no.3, 2007 , pp. 204-212 More about this Journal
Abstract
The study was carried out to investigate the ratio of ethanol to n-propanol in blood and urine specimens, and developed a method for distinguishing ingested ethanol from artifactual ethanol in urine samples. In case of no urinary ethanol was detected, the ratio of ethanol to n-propanol concentration was about 12~20 times higher than those of blood. Therefore, it might be a good method to determine whether the detected ethanol is from drinking or from microbial fermentation. During the metabolism of ethanol, the levels of the metabolite of serotonin (5-hydroxytryptamine, 5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) were decreased, while 5-hydroxytryptophol (5-HTOL) was increased. The levels of 5-HTOL/5-HIAA in urine samples of drinking suspects were greater than 1, in that of no drinking suspects were less than 1.
Keywords
n-propanol; serotonin; 5-HIAA; 5-HTOL;
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