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http://dx.doi.org/10.5806/AST.2007.20.3.198

Quantitative analysis of 3-MCPD in water using LC-MS  

Park, Gyo-Beom (Center for Chemical Analysis, Korea Research Institute of Chemical Technology)
Kim, Yong-Hwa (Toxicology Research Division, Korea Institute of Toxicology)
Kim, Jin-Sung (Toxicology Research Division, Korea Institute of Toxicology)
Jeong, Ja-Young (Department of Toxicologic Patholog, National Institute of Toxicological Research, Korea Food and Drug Administration)
Kim, Choong-Yong (Toxicology Research Division, Korea Institute of Toxicology)
Lee, Sueg-Geun (Center for Chemical Analysis, Korea Research Institute of Chemical Technology)
Publication Information
Analytical Science and Technology / v.20, no.3, 2007 , pp. 198-203 More about this Journal
Abstract
The analysis method of 3-Monochloropropane-1,2-diol (3-MCPD) compound in water was developed using liquid chromatography with mass spectrometric detection. Aqueous solution was controlled in strong basic condition with sodium hydroxide, and then $25{\mu}L$ of benzoyl chloride was added to the solution for the derivatization of 3-MCPD. The derivative was extracted using pentane and analyzed by the selected ion monitoring (SIM) method of LC-MS. The results of analyses showed that the calibration curves was in the range of 1.0 to $100{\mu}g/mL$ with a good linearity (correlation coefficient of $r^2=0.992$) and limit of detection was below $0.01{\mu}g/mL$. The recoveries of this analysis method by LC-MS were 92.3-98.0 %.
Keywords
3-Monochloropropane-1,2-diol; 3-MCPD; LC-MS. benzoyl chloride;
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